At a Glance
- Tasks: Lead animal model studies and oversee preclinical research in oncology.
- Company: Innovative biotechnology company focused on impactful cancer research.
- Benefits: Competitive salary, collaborative environment, and opportunities for professional growth.
- Other info: Join a dynamic team dedicated to advancing translational science.
- Why this job: Make a real difference in cancer treatment through cutting-edge research.
- Qualifications: PhD in relevant field and 5+ years of hands-on experience in cell biology.
The predicted salary is between 60000 - 80000 £ per year.
A growing biotechnology company is seeking an experienced Senior Cell Biologist to lead animal model and translational biology programmes across multiple oncology indications. This is a high-impact opportunity for a scientist who can bridge in vitro cell biology with in vivo pharmacology, designing and overseeing preclinical studies that will generate critical efficacy, biodistribution, and translational data to support progression towards the clinic.
Key Responsibilities:
- Design, oversee and interpret in vivo efficacy and biodistribution studies across multiple oncology programmes
- Lead animal model studies, including coordination and management of outsourced CRO activities
- Develop and implement immunogenicity assessment strategies, including anti-Cas human PBMC ELISpot assays for pre-existing immunity and redosing scenarios
- Establish and manage patient-derived organoid (PDO) assay platforms to evaluate therapeutic selectivity
- Define pharmacodynamic strategies, including tumour molecular analysis and biomarker monitoring
- Perform hands-on cell biology experiments to support translational research programmes
- Collaborate cross-functionally to integrate preclinical data and inform development strategies
Essential Requirements:
- PhD in Cancer Biology, Pharmacology, Immunology or a related scientific discipline
- 5+ years of hands-on experience in both in vivo models and in vitro cell biology
- Strong experience working with oncology models, including bladder, liver and/or lung cancer models
- Experience with local or intravesical delivery approaches in rodent models
- Expertise in biodistribution study design and tissue analysis techniques, including qPCR and IHC
- Hands-on experience with patient-derived organoid culture and functional assays
- Experience with immunology assays such as ELISpot
Desirable Experience:
- Experience supporting GLP-adjacent or GLP-compliant preclinical studies
- Knowledge of animal study regulatory frameworks, including Australian or US requirements
- Previous experience working on gene therapy or gene editing programmes in vivo
This is an excellent opportunity for a translational scientist looking to take ownership of impactful preclinical programmes within a collaborative and innovative biotechnology environment.
Contact Details:
Barrington James Drug Discovery & Preclinical Recruitment Team
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist in City of London
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We think you need these skills to ace Senior Scientist in City of London
Some tips for your application 🫡
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