At a Glance
- Tasks: Lead and manage enterprise applications to support corporate and commercial functions.
- Company: Join Autolus, a pioneering biopharmaceutical company transforming cancer therapy.
- Benefits: Enjoy a competitive salary, performance bonuses, and comprehensive benefits.
- Other info: Flexible hybrid working model with opportunities for professional growth.
- Why this job: Make a real impact in healthcare while working in a dynamic, inclusive environment.
- Qualifications: 7-12 years of experience with enterprise applications and strong vendor management skills.
The predicted salary is between 70000 - 90000 £ per year.
Our team are passionate in the pursuit of excellence and in pushing the boundaries of cancer therapy and autoimmune disease to deliver life-changing treatments to patients. Whilst working at Autolus you will enjoy a flexible, diverse and dynamic working environment which actively promotes creativity, leadership and teamwork.
About Autolus
Autolus is a biopharmaceutical company, advancing innovative therapies at both clinical and commercial stages of development, focused on next-generation, programmed T cell therapies for the treatment of cancer. Using a broad suite of proprietary and modular T cell programming technologies, the company is engineering precisely targeted, controlled, and highly active T cell therapies designed to better recognize cancer cells, break down their defence mechanisms, and eliminate these cells. Autolus has a pipeline of product candidates in development for the treatment of haematological malignancies, solid tumours, and autoimmune diseases.
Role Summary
The Senior Applications Manager is responsible for owning and overseeing a portfolio of enterprise applications, including systems such as CRM, ERP, HRIS, and their associated integrations, which support key corporate and commercial business functions. This role is accountable for ensuring that these applications consistently deliver reliable, high-quality, secure, and cost-effective outcomes for the organisation. While not directly responsible for day-to-day support operations, the role provides strategic direction to service delivery teams and holds them accountable for performance, service quality, and adherence to agreed SLAs and operational standards.
A key aspect of the position is maintaining oversight of application health, performance, resilience, and stability across the portfolio, ensuring systems remain fit for purpose, compliant, and aligned with evolving business needs. The role is also responsible for establishing, maturing, and embedding effective governance frameworks and operational rhythms that support the ongoing health, stability, and continuous improvement of applications within a BAU environment. This includes implementing structured review cadences, service governance forums, risk and issue management processes, change oversight, vendor performance management, and KPI reporting mechanisms to drive operational excellence and accountability across the application landscape.
The Senior Applications Manager will chair or contribute to governance forums and ensure appropriate controls, policies, and standards are implemented across the application portfolio. This includes ensuring that application changes are assessed, prioritised, approved, and delivered in line with business priorities, regulatory expectations, cybersecurity requirements, and IT governance standards. The role works closely with business stakeholders to understand strategic priorities, shape demand, and ensure application roadmaps, investment decisions, and enhancement activities are aligned with organisational objectives. In addition, the role acts as a key escalation and decision-making point for application-related risks, issues, technical debt, and continuous improvement opportunities across the portfolio.
Key Responsibilities
- Support Oversight (via Service Delivery)
- Partner with Service Delivery Managers (SDMs) and support teams to ensure strong application support performance
- Define expectations for support quality, SLAs, and user experience
- Review incident trends and ensure systemic issues are identified and resolved
- Hold vendors and support teams accountable for outcomes, not just activity
- Business Partnering and Demand Prioritization
- Work closely with Business Stakeholders (BSOs) to understand day-to-day operational needs
- Translate needs into a prioritized backlog based on business impact and urgency
- Make clear trade-offs across competing demands and limited capacity
- Ensure delivery is high quality and cost-conscious, not just fast
- Financial Ownership & Optimization
- Own budget for applications, including licenses, vendors, and run costs
- Identify and drive opportunities for cost optimization and efficiency
- Ensure the application landscape scales in a financially sustainable way as the business grows
- Manage renewals, contracts, and commercial negotiations
- Vendor & Contract Management
- Manage third-party vendors and partners delivering support and enhancements
- Negotiate and manage contracts, scope, and commercial terms
- Ensure vendors are delivering value for money and meeting expectations
- Drive accountability and performance improvements where needed
- Data-Driven Decision Making
- Use data (ticket trends, usage metrics, cost data, performance metrics) to guide decisions
- Continuously reassess priorities and approaches based on new information
- Be willing to challenge assumptions and adjust direction when needed
- Integration & System Landscape Oversight
- Maintain visibility across integrations between systems (e.g., CRM, ERP, HRIS)
- Ensure changes are considered in the context of the broader application ecosystem
- Work with technical teams to manage dependencies and avoid downstream issues
Demonstrated skills and competencies
- E – Essential
- P – Preferred
Experience
- 7–12+ years working with enterprise applications (CRM, ERP, HRIS, or similar) (E)
- Experience owning or managing application portfolios, not just individual systems (E)
- Strong experience managing third-party vendors and commercial relationships (E)
- Experience working in environments with separate support/service delivery functions (E)
- Experience in regulated industries (e.g., pharma, biotech, healthcare) (P)
- Familiarity with compliance requirements (e.g., GxP, SOX) (P)
- Experience with systems such as Salesforce, Dynamics 365, Workday, or similar (P)
Qualifications
- Bachelor’s degree in Information Technology, Computer Science, Business Information Systems, or a related discipline (P) + Equivalent professional experience may be accepted in place of a degree
Skills/Specialist knowledge
- Strong ability to prioritize and make trade-offs across competing business needs (E)
- Comfortable operating with budget ownership and cost accountability (E)
- Data-driven mindset with the ability to turn insights into action (E)
- Excellent stakeholder management and influencing skills (E)
- Ability to operate across both business and technical contexts (E)
Autolus is committed to the protection of the personal information that we collect & process and we are fully compliant with General Data Protection Regulations (GDPR). Autolus is committed to providing an inclusive and fair workplace for all. We are an equal opportunity employer and do not discriminate on the basis of race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic. We also provide reasonable accommodations throughout the recruitment process. Autolus’ success is driven by equality and inclusion; we believe all voices are of equal value and must be heard. Whilst operating with focus and integrity, we are committed to improving diversity and inclusion within our business and our industry.
Senior Business Applications Manager in London employer: Autolus Limited
Autolus is an exceptional employer, offering a flexible and dynamic work environment in the heart of London, where creativity and teamwork are at the forefront of our mission to develop life-changing cancer therapies. Employees benefit from a competitive salary, performance-related bonuses, and a comprehensive benefits package, alongside ample opportunities for professional growth and development within a diverse and inclusive culture that values every voice.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Business Applications Manager in London
✨Tip Number 1
Network like a pro! Reach out to your connections in the industry, attend relevant events, and don’t be shy about letting people know you’re on the hunt for a Senior Business Applications Manager role. You never know who might have the inside scoop on an opportunity!
✨Tip Number 2
Prepare for interviews by researching Autolus and its mission. Understand their focus on cancer therapy and autoimmune diseases, and think about how your experience aligns with their goals. This will help you stand out as a candidate who truly gets what they’re about.
✨Tip Number 3
Practice your pitch! Be ready to explain how your skills in managing enterprise applications can drive results at Autolus. Highlight your experience with CRM, ERP, and vendor management, and show them you’re the perfect fit for their team.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, it shows you’re serious about joining the Autolus family and contributing to their mission of delivering life-changing treatments.
We think you need these skills to ace Senior Business Applications Manager in London
Some tips for your application 🫡
Tailor Your Application:Make sure to customise your CV and cover letter for the Senior Business Applications Manager role. Highlight your experience with enterprise applications and how it aligns with our mission at Autolus.
Showcase Your Achievements:Don’t just list your responsibilities; share specific achievements that demonstrate your impact in previous roles. We love to see how you've driven results and improved processes!
Be Clear and Concise:Keep your application clear and to the point. Use bullet points where possible to make it easy for us to read through your qualifications and experiences quickly.
Apply Through Our Website:We encourage you to apply directly through our website. It’s the best way for us to receive your application and ensures you’re considered for the role without any hiccups!
How to prepare for a job interview at Autolus Limited
✨Know Your Applications Inside Out
Before the interview, make sure you have a solid understanding of the enterprise applications mentioned in the job description, like CRM, ERP, and HRIS. Familiarise yourself with their functionalities and how they support business operations. This will help you demonstrate your expertise and show that you're ready to take ownership of the application portfolio.
✨Showcase Your Stakeholder Management Skills
Prepare examples of how you've successfully collaborated with business stakeholders in the past. Highlight your ability to translate operational needs into prioritised backlogs and how you've managed competing demands. This will illustrate your capability to work closely with teams and ensure high-quality delivery.
✨Demonstrate Financial Acumen
Be ready to discuss your experience with budget ownership and cost optimisation. Share specific instances where you've driven efficiencies or negotiated contracts with vendors. This will show that you understand the financial aspects of managing applications and can contribute to the organisation's sustainability.
✨Emphasise Data-Driven Decision Making
Prepare to talk about how you've used data to guide your decisions in previous roles. Bring examples of how you've analysed ticket trends or performance metrics to reassess priorities. This will highlight your analytical skills and your ability to adapt based on new information, which is crucial for the Senior Applications Manager role.
