Atrium is seeking a highly motivated Senior Scientist to join their Biopharmaceutics Modelling & Simulation team in Sandwich, Kent. This is an exciting opportunity to contribute to the development and optimisation of innovative drug products by applying cutting-edge Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutics Modelling (PBBM) approaches.
The successful candidate will play a key role in supporting model-informed drug development across all stages of the pharmaceutical lifecycle, working within multidisciplinary teams to drive scientific and regulatory decision-making
Key Responsibilities
- Develop, verify, and apply PBPK and PBBM models using software platforms such as Simcyp, GastroPlus, or equivalent tools.
- Support predictions related to oral absorption, food effects, bioavailability, formulation bridging, dissolution performance, particle size specifications, and virtual bioequivalence.
- Conduct model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to support development decisions.
- Collaborate closely with laboratory scientists to design and interpret in vitro studies that support model development and verification.
- Contribute to clinically relevant dissolution method development and in vitro-in vivo correlations where appropriate.
- Present modelling outcomes through technical reports, project team meetings, regulatory submissions, and scientific publications.
- Drive innovation in modelling methodologies, automation, and data-driven approaches, including AI/ML-enabled predictive tools.
Required Experience & Qualifications
- PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering, or a related scientific discipline.
- Strong expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development.
- In-depth understanding of oral absorption, dissolution, permeability, biopharmaceutics, and pharmacokinetics.
- Hands-on experience with modelling platforms such as Simcyp, GastroPlus, PK-Sim, or similar software.
- Proven ability to apply modelling strategies to solve pharmaceutical development challenges.
- Excellent scientific communication and technical writing skills
- Experience supporting regulatory submissions involving PBPK or PBBM analyses.
- Knowledge of virtual bioequivalence studies and clinically relevant dissolution specifications.
- Programming experience with Python, R, MATLAB, or similar scientific tools.
- Exposure to machine learning and data science applications within pharmaceutical development.
- Experience across diverse drug modalities, including poorly soluble compounds, peptides, enabling formulations, or complex dosage forms.
Senior Scientist employer: Atrium
Atrium is an exceptional employer that fosters a culture of growth and collaboration, making it an ideal place for a Catastrophe Analyst to thrive. With a commitment to flexible working arrangements and a strong focus on diversity, equity, and inclusion, employees are empowered to pursue their passions while contributing to meaningful work in the insurance industry. The opportunity to engage in innovative analytics development and support critical risk management initiatives ensures that team members play a vital role in shaping the future of the business.
