At a Glance
- Tasks: Lead innovative toxicology strategies for groundbreaking cancer therapies.
- Company: Join AstraZeneca, a leader in the fight against cancer with a rich pipeline of treatments.
- Benefits: Enjoy flexible working options and a vibrant office culture that fosters growth.
- Other info: Be part of a diverse team driving scientific breakthroughs and improving global health.
- Why this job: Make a real impact on patients' lives while collaborating with top experts in the field.
- Qualifications: DABT or PhD in relevant fields with experience in non-clinical safety for immune-Oncology.
The predicted salary is between 72000 - 108000 £ per year.
Location: Cambridge - UK, Gaithersburg - USA
At AstraZeneca, it is our bold ambition to eliminate cancer as a cause of death. This is underpinned by our rich pipeline aimed to deliver innovative treatment options for Oncology patients.
We are looking for a motivated and passionate individual to join us as a Director, Project Toxicologist, Immune Oncology Safety with a focus on delivery of transformative immunotherapies to advance our portfolio of innovative anti-cancer medicines in Oncology R&D. You will provide non-clinical safety expertise for our diverse Oncology portfolio with particular focus on T cell engagers (TCE) and other Immuno-Oncology (IO) therapeutics. You will play an integral role in driving progression and acceleration of drug projects through discovery and development by designing innovative regulatory toxicology strategies to address drug target- and modality-related risks.
The position can be based at one of our vibrant strategic R&D sites in Gaithersburg (MD), or Cambridge (the UK). Within AstraZeneca we place a strong emphasis on talent development. You will be able to develop your knowledge and skills by working together with experts and leaders in Immunology R&D, safety science, pharmacology, toxicology, drug discovery and development, imaging, pathology, and translational science.
What you will do
- As a core member of multi-disciplinary oncology drug development teams, you will design, deliver, and interpret innovative toxicology strategies to predict, assess and mitigate target- and modality related safety risks.
- Develop and implement innovative solutions to combine regulatory toxicology with ground-breaking science and technologies to progress novel drug candidates to the clinic and through development to the market, in line with business needs.
- To influence project strategy and decision making, you will communicate clear positions on integrated risk assessments in various formats including informing internal decision-making governance bodies and interacting with external health authorities.
- Delivering quality nonclinical summaries and other high-level regulatory documents for internal decision bodies and external health authorities.
- Maintain expertise in regulatory requirements and preclinical safety approaches applied to Drug Candidates and awareness of industry trends.
- Additional responsibilities include providing experienced nonclinical evaluation of in-licensing and out-licensing opportunities and to provide mentorship and guidance to emerging toxicologists with respect to the regulatory environment and support their career growth and development in Immune oncology department.
Requirements for this role
- DABT or PhD in toxicology, immunology, or immunopharmacology with several years of experience in the pharmaceutical or biotechnology industry working as a non-clinical safety lead, supporting immune-Oncology programs with planning, execution, interpretation and communication of regulatory toxicology data.
- A proven understanding of drug development and a track record of delivering multiple toxicology programs to IND and through clinical development.
- High level of knowledge and expertise in designing toxicology strategies and delivering in vitro/in vivo and risk assessment of immune related risks/adverse events, driven by mechanism and/or TCE.
- Expertise in immunology or oncology, including T-cell biology.
- Ability to solve problems in a goal-focused fashion with willingness to challenge conventional thinking and capacity to coordinate tasks across multiple projects.
- Excellent verbal and written communication, interpersonal, and influencing skills.
- Adopting an inclusive and collegiate working style, and a desire to drive own and support others' development.
Desirable in the role
- Experience with TCE and other large molecules will be desirable.
- In addition to possessing scientific competence, we value individuals who can contribute to our inclusive, positive, and collaborative working environment.
- DABT is considered an advantage.
When we put unexpected teams in the same room, we fuel ambitious thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility.
Join us in our unique and ambitious world. Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference by fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Our combination of curiosity and courage drives us to explore new possibilities without fear of failure. We celebrate our successes and learn from our failures along the way. Our inclusive environment allows us to work seamlessly as one team, using diverse global knowledge to create the greatest impact on disease.
If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be. Apply now!
What is next?
Are you ready to make a difference? Apply today and join us in our mission to improve global public health!
We welcome your applications not later than 8th June 2025.
Date Posted: 23-May-2025
Closing Date: 08-Jun-2025
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
Director, Project Toxicologist, Immune Oncology safety in Cambridge employer: AstraZeneca
AstraZeneca is an exceptional employer, dedicated to fostering a collaborative and inclusive work culture that empowers employees to thrive. With a strong emphasis on talent development, you will have the opportunity to work alongside leading experts in Immunology R&D, enhancing your skills while contributing to groundbreaking cancer therapies. Our vibrant locations in Cambridge and Gaithersburg not only offer a dynamic work environment but also provide unique opportunities for personal and professional growth, making it an ideal place for passionate individuals looking to make a meaningful impact in healthcare.
StudySmarter Expert Advice🤫
We think this is how you could land Director, Project Toxicologist, Immune Oncology safety in Cambridge
✨Tip Number 1
Network with professionals in the oncology and toxicology fields. Attend industry conferences or webinars where you can meet experts from AstraZeneca and other companies. Building these connections can provide insights into the company culture and potentially lead to referrals.
✨Tip Number 2
Stay updated on the latest trends in immuno-oncology and regulatory toxicology. Follow relevant journals, blogs, and news outlets to understand the current challenges and innovations in the field. This knowledge will help you engage in meaningful conversations during interviews.
✨Tip Number 3
Prepare to discuss your previous experiences in drug development and toxicology strategies. Be ready to share specific examples of how you've addressed safety risks in past projects, as this will demonstrate your expertise and problem-solving skills relevant to the role.
✨Tip Number 4
Familiarise yourself with AstraZeneca's mission and values, particularly their commitment to innovation in cancer treatment. Tailor your discussions to reflect how your personal goals align with their vision, showcasing your passion for making a difference in patients' lives.
We think you need these skills to ace Director, Project Toxicologist, Immune Oncology safety in Cambridge
Some tips for your application 🫡
Tailor Your CV:Make sure your CV highlights relevant experience in toxicology, immunology, and drug development. Use specific examples that demonstrate your expertise in designing toxicology strategies and your understanding of immune-Oncology programs.
Craft a Compelling Cover Letter:In your cover letter, express your passion for advancing cancer treatments and how your background aligns with AstraZeneca's mission. Mention specific projects or experiences that showcase your ability to influence project strategy and decision-making.
Highlight Leadership Skills:Since the role involves mentoring emerging toxicologists, emphasise any leadership or mentorship experiences you have. Discuss how you've supported others' development in previous roles, showcasing your collaborative working style.
Showcase Communication Skills:Given the importance of clear communication in this role, provide examples of how you've effectively communicated complex scientific information to various stakeholders. This could include presentations, reports, or interactions with regulatory bodies.
How to prepare for a job interview at AstraZeneca
✨Showcase Your Expertise
Make sure to highlight your qualifications, especially your DABT or PhD in toxicology, immunology, or immunopharmacology. Discuss your experience in the pharmaceutical or biotechnology industry, particularly in immune-Oncology programs, to demonstrate your fit for the role.
✨Prepare for Technical Questions
Expect to be asked about your understanding of drug development and toxicology strategies. Brush up on your knowledge of T cell biology and risk assessment of immune-related risks, as these are crucial for the position.
✨Communicate Clearly
Since the role involves influencing project strategy and decision-making, practice articulating your thoughts clearly. Be prepared to discuss how you would communicate integrated risk assessments to both internal teams and external health authorities.
✨Emphasise Team Collaboration
AstraZeneca values an inclusive and collaborative working environment. Share examples of how you've worked effectively in multi-disciplinary teams and supported the development of others, showcasing your ability to foster a positive team dynamic.
