Senior Scientist in Trace Analysis Mass Spectrometry in Cheshire

This job is with AstraZeneca, an inclusive employer and a member of myGwork – the largest global platform for the LGBTQ+ business community. Please do not contact the recruiter directly.Job Title: Senior Scientist in Trace Analysis Mass Spectrometry
Location: Macclesfield
Salary: Competitive
Introduction to role:
Are you ready to use separation science and mass spectrometry to quantify trace impurities that protect patients and accelerate medicines to market? Based at our Macclesfield, UK campus, you will apply your expertise to generate decisive, high-quality data that directly shapes product understanding and control strategies.
You will join an analytical team that partners across development and commercialisation, translating complex trace-level signals into clear, evidence-led decisions. Your work will influence how products are designed, controlled and released, ensuring the right outcomes for patients and the business. Do you want to see your conclusions inform regulatory submissions and help define robust strategies for known and unknown impurities?
Accountabilities:
* Trace Impurity Quantification: Develop, review and apply mass spectrometry methods to quantify trace-level components in complex matrices, supporting both development projects and marketed products with reliable, sensitive and specific assays.
* Separation Science and Sample Preparation: Design and optimise sample-preparation and chromatographic approaches that resolve challenging low-level analytes, ensuring reproducible outcomes and robust method performance.
* Investigation and Characterisation: Investigate unexpected results and unknown impurities; conduct targeted characterisation and structure confirmation to explain signals and strengthen scientific rationale.
* Data Interpretation and Decision Influence: Translate analytical outputs into clear, defensible conclusions that drive product understanding, impurity control strategies and regulatory documentation.
* Cross-Functional Collaboration and External Oversight: Work closely with project teams and partner functions to deliver on timelines;