At a Glance
- Tasks: Lead innovative PKPD modeling to advance cancer drug discovery and patient outcomes.
- Company: Join AstraZeneca, a global leader in biopharmaceuticals focused on life-changing medicines.
- Benefits: Competitive salary, excellent benefits, and opportunities for professional growth.
- Other info: Inclusive environment with a focus on collaboration and personal accountability.
- Why this job: Make a real impact in oncology and contribute to groundbreaking cancer treatments.
- Qualifications: Ph.D. in relevant fields with experience in modeling and simulation.
The predicted salary is between 60000 - 80000 £ per year.
Location: Cambridge, UK
Competitive Salary & Excellent Company Benefits
Do you have a passion for PKPD modeling and DMPK science, applied to Cancer biology? Would you like to apply your expertise to impact the lives of patients in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!
We currently have an exciting opportunity for someone who has a passion for PKPD modeling and DMPK science, applied to Cancer biology, ideally with some experience of working with biologics, drug projects to join our team.
About AstraZeneca
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team.
Oncology DMPK department
The Oncology DMPK department provides drug metabolism & pharmacokinetic, as well as translational PKPD modeling & simulation support to our portfolio. Be part of fulfilling our ambition to be world leaders in Oncology. There are countless new indications and targets in our game-changing pipeline. We deliver this value through launch excellence, commercial effectiveness and maximising the lifecycle. By leveraging our commercialised portfolio, we are confident we can change the practice of medicine and redefine cancer treatment. We’re brave disruptors – entrepreneurial, courageous and pioneering in our approach. Here you have the opportunity to step up, take personal accountability and lead changes in our ever-evolving environment.
What You’ll Do
As a Senior Scientist, Translational PKPD Modeling & DMPK you will have the opportunity to apply your expertise in PKPD modeling and simulation to advance our understanding of cancer biology and accelerate drug discovery. Your day-to-day role is to provide projects with specialist modeling input into exploring the PK/PD/Efficacy in pre-clinical models and using these models to iteratively build an understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.
- Represent Oncology DMPK, providing scientific leadership in cross-functional and external collaborations.
- Develop and utilize PKPD models to explore the effects of target and pathway modulation, defining candidate drug target profiles.
- Predict human dose and regimen, contributing to exposure and pharmacodynamic biomarker-based decision-making for early clinical trials.
- Drive learning through back-translation of clinical exposure and pharmacodynamic data, offering strategic options for future clinical testing.
- Present findings through publications, patents, and lectures, enhancing the visibility of AstraZeneca’s translational research.
What You Bring
- Ph.D. in Modeling & Simulation, systems biology, quantitative pharmacology, pharmacometrics, (chemical) engineering, physics, pharmaceutical sciences, or applied mathematics.
- Relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting.
- Experience in a project-facing role within pharmaceutical R&D.
- Strong understanding of DMPK and pharmacology in drug discovery.
- Proficiency with tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP.
- Excellent interpersonal, communication, and leadership skills, with a passion for collaborative problem-solving.
Interested? Apply by submitting your CV before 17th May 2026.
Date Posted: 01-May-2026
Closing Date: 17-May-2026
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
Senior Scientist, Translational PKPD in Cambridge employer: AstraZeneca
AstraZeneca is an exceptional employer located in Cambridge, UK, offering a dynamic work culture that fosters courage, curiosity, and collaboration. Employees benefit from competitive salaries, excellent company benefits, and ample opportunities for professional growth within a pioneering biopharmaceutical environment focused on transforming cancer treatment. Join us to make a meaningful impact on patient lives while working alongside passionate experts in the field.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist, Translational PKPD in Cambridge
✨Tip Number 1
Network like a pro! Reach out to your connections in the industry, especially those who work at AstraZeneca or similar companies. A friendly chat can lead to insider info about job openings and even referrals.
✨Tip Number 2
Prepare for interviews by diving deep into PKPD modeling and DMPK science. Brush up on recent advancements in oncology and be ready to discuss how your expertise can contribute to AstraZeneca's mission of changing cancer treatment.
✨Tip Number 3
Showcase your passion! During interviews, share specific examples of how you've applied your skills in real-world scenarios. This will help you stand out as someone who’s not just qualified but genuinely excited about the role.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, it shows you’re serious about joining the AstraZeneca team.
We think you need these skills to ace Senior Scientist, Translational PKPD in Cambridge
Some tips for your application 🫡
Tailor Your CV:Make sure your CV reflects the specific skills and experiences that align with the Senior Scientist role. Highlight your expertise in PKPD modeling and DMPK science, especially as it relates to cancer biology.
Craft a Compelling Cover Letter:Use your cover letter to tell us why you're passionate about this position and how your background makes you a great fit. Be sure to mention any relevant projects or experiences that showcase your skills in translational PKPD modeling.
Showcase Your Collaboration Skills:Since we value teamwork, make sure to include examples of how you've successfully collaborated in cross-functional teams. This will demonstrate your ability to lead and contribute effectively in our dynamic environment.
Apply Through Our Website:We encourage you to apply directly through our website for the best chance of being noticed. It’s the easiest way for us to keep track of your application and ensure it gets to the right people!
How to prepare for a job interview at AstraZeneca
✨Know Your PKPD Inside Out
Make sure you brush up on your knowledge of PKPD modeling and DMPK science, especially as it relates to oncology. Be prepared to discuss specific models you've worked with and how they apply to cancer biology. This will show your passion and expertise in the field.
✨Showcase Your Collaborative Spirit
AstraZeneca values collaboration, so be ready to share examples of how you've successfully worked in cross-functional teams. Highlight any leadership roles you've taken on and how you’ve contributed to team success, especially in project-facing roles.
✨Prepare for Technical Questions
Expect technical questions related to your experience with tools like WinNonLin, MATLAB, or SimCYP. Brush up on your practical knowledge and be ready to explain how you've used these tools in your previous projects to drive results.
✨Communicate Your Vision
Articulate your understanding of the drug discovery process and how your work can impact patient outcomes. Be prepared to discuss your vision for advancing cancer treatment through innovative PKPD modelling and how you can contribute to AstraZeneca's mission.
