At a Glance
- Tasks: Design and synthesise complex molecules for innovative cancer therapies.
- Company: AstraZeneca, a global leader in oncology research.
- Benefits: Competitive salary, collaborative environment, and opportunities for skill development.
- Other info: Join a dynamic team at the Cambridge Biomedical Campus.
- Why this job: Make a real impact in early drug discovery and patient care.
- Qualifications: PhD in synthetic organic chemistry and experience in complex molecule synthesis.
The predicted salary is between 60000 - 80000 £ per year.
AstraZeneca is seeking a Senior Scientist – Synthetic Chemist to join our site on the Cambridge Biomedical Campus. You will join the Oncology Targeted Discovery group within Early Oncology, supporting pioneering research in the synthesis of novel payloads and linker‑payloads for Antibody‑Drug Conjugates (ADCs).
This hands‑on, laboratory‑based role is integral to our ADC chemistry efforts. You will design and synthesize complex small molecules, developing innovative payloads and linker‑payload architectures to accelerate new therapeutic options in oncology. You'll be embedded in a collaborative team environment, driving forward experimental work and contributing to the delivery of high‑impact targets.
Key Responsibilities- Plan and perform multi‑step synthetic routes to deliver complex payloads and linker‑payload constructs with high purity and reproducibility.
- Apply advanced organic synthesis, purification, and analytical characterization (including NMR, LC‑MS), working with challenging and structurally diverse molecules.
- Collaborate closely with multidisciplinary scientists across chemistry and biology, sharing data and insights to support ADC design and optimization.
- Maintain detailed experimental records, SHE standards, and contribute to technical reports summarizing synthetic approaches and findings.
- PhD in synthetic organic chemistry (or equivalent experience), ideally with postdoctoral or industry experience in complex molecule synthesis.
- Extensive experience in synthetic route development, troubleshooting challenging chemistry, and characterizing compounds at each stage.
- Enjoy bench chemistry and thrive in a dynamic laboratory setting, handling the scale‑up and purification of potent molecules.
- Demonstrates clear scientific communication; collaboratively engages with project teams.
Join a global leader in oncology research at the heart of the Cambridge Biomedical Campus. Work with talented scientists at the cutting edge of targeted therapies, contributing to meaningful advances for patients. This position offers a unique opportunity to develop your skills further in complex molecule synthesis, expand your scientific network, and make an impact in early drug discovery.
Salary: Negotiable
Senior Scientist (Synthetic Chemistry) in Cambourne employer: AstraZeneca
AstraZeneca is an exceptional employer, offering a dynamic work culture that fosters innovation and collaboration in the heart of Cambridge. Employees benefit from extensive professional development opportunities, a commitment to diversity and inclusion, and the chance to make a meaningful impact in the pharmaceutical industry through cutting-edge research and AI integration.
