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- Tasks: Join a dynamic team to develop and purify innovative biopharmaceuticals.
- Company: AstraZeneca, a leader in biopharmaceutical development with a collaborative culture.
- Benefits: 12-month fixed-term contract with competitive salary and professional growth opportunities.
- Why this job: Make a real impact in drug development while working with cutting-edge technologies.
- Qualifications: Degree in Life Science or Engineering; relevant experience is a plus.
- Other info: Engage in exciting projects and collaborate with global colleagues.
The predicted salary is between 36000 - 60000 £ per year.
Be part of the Cambridge Research Support and Scale-up Team, within the Biopharmaceutical Development Department, a cross-functional group focusing on upstream protein expression, bioreactor operations, and downstream purification. We generate recombinant proteins and novel therapeutic modalities to support internal programs across all stages of drug development. Our team is also responsible for the development and implementation of exciting new technologies around mammalian protein expression, bioreactor processing, product capture, polishing, and formulation of proteins and other therapeutic modalities. This role focuses on downstream purification at large-scale, having a hands-on laboratory role as part of a cross-functional team and being responsible for:
- Primary clarification using disk stack centrifuge and depth filters of bioreactors from 50-500L
- Recombinant protein purification using Bioprocess and AKTA pilot scale systems
- Development of polishing steps for purity enrichment
- Detailed production at scale prior to clinical manufacture
- Ultrafiltration / Diafiltration using bench and pilot scale systems
- Product and process characterization using SEC-HPLC, UV-VIS, Osmolarity device and other techniques
- Contributing to technology development projects to further develop in-house technologies
- Record all experiments accurately, clearly and in a timely fashion; prepare data summaries and appropriate reports according to project requirements and meeting required timelines.
- Presentation of data at informal group meetings for discussion and at departmental meetings.
- Actively contributing to the scientific direction of Biopharmaceutical Development (BPD) / Drug Substance Development Department.
- Implement and promote AstraZeneca's health and safety practices including the regulations governing COSHH, biological agents and genetically modified organisms as detailed in the relevant risk assessments.
Additional Responsibilities: You will play a significant role in supporting Tox supply activities and pilot scale for primary clarification, purification, and formulation of proteins. In addition, you will be involved in further development and improvement of the latest technologies. Liaising with both local and global colleagues across the business.
Qualifications: Relevant university degree (e.g., BSc/MSc/PhD) in Life Science, Chemical or Bioprocess Engineering, with relevant industrial experience desirable.
Senior Scientist (Large-Scale Purification) - 12-month FTC employer: AstraZeneca UK Limited
Contact Detail:
AstraZeneca UK Limited Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Scientist (Large-Scale Purification) - 12-month FTC
✨Tip Number 1
Network like a pro! Reach out to current employees at the company through LinkedIn or professional groups. A friendly chat can give you insider info and maybe even a referral!
✨Tip Number 2
Prepare for interviews by practising common questions related to large-scale purification and bioprocessing. We recommend using the STAR method to structure your answers – it’ll help you showcase your experience effectively.
✨Tip Number 3
Showcase your hands-on lab skills! Be ready to discuss specific techniques you've used, like ultrafiltration or SEC-HPLC, and how they relate to the role. This will demonstrate your practical knowledge and fit for the team.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, we love seeing candidates who are proactive about their job search!
We think you need these skills to ace Senior Scientist (Large-Scale Purification) - 12-month FTC
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the Senior Scientist role. Highlight your experience in downstream purification and any relevant technologies you've worked with. We want to see how your skills match what we're looking for!
Showcase Your Experience: In your cover letter, give us a glimpse of your hands-on laboratory experience, especially with large-scale purification processes. Share specific examples that demonstrate your expertise and how you can contribute to our team.
Be Clear and Concise: When writing your application, keep it clear and to the point. Use straightforward language and avoid jargon unless it's relevant. We appreciate clarity as much as we appreciate technical knowledge!
Apply Through Our Website: Don't forget to apply through our website! It’s the best way for us to receive your application and ensures you’re considered for the role. Plus, it’s super easy to do!
How to prepare for a job interview at AstraZeneca UK Limited
✨Know Your Science
Make sure you brush up on your knowledge of downstream purification processes, especially those involving disk stack centrifuges and AKTA systems. Be ready to discuss your hands-on experience with these technologies and how they relate to the role.
✨Showcase Your Team Spirit
This position is all about collaboration within a cross-functional team. Prepare examples of how you've successfully worked in teams before, particularly in biopharmaceutical settings. Highlight your ability to communicate effectively with colleagues from different backgrounds.
✨Be Data-Driven
Since you'll be responsible for recording experiments and preparing data summaries, come prepared to discuss your experience with data analysis tools like SEC-HPLC and UV-VIS. Share specific instances where your data-driven approach led to successful outcomes.
✨Safety First!
Familiarise yourself with health and safety practices relevant to biopharmaceutical development, including COSHH regulations. Be ready to discuss how you've implemented safety protocols in previous roles, as this will show your commitment to maintaining a safe working environment.