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- Tasks: Join a dynamic team to develop and purify innovative biopharmaceuticals.
- Company: AstraZeneca, a leading biopharmaceutical company focused on cutting-edge research.
- Benefits: 12-month contract with competitive salary and opportunities for professional growth.
- Why this job: Make a real impact in drug development while working with advanced technologies.
- Qualifications: Degree in Life Science or Engineering with relevant experience preferred.
- Other info: Collaborative environment with a focus on innovation and safety.
The predicted salary is between 36000 - 60000 £ per year.
Be part of the Cambridge Research Support and Scale-up Team, within the Biopharmaceutical Development Department, a cross-functional group focusing on upstream protein expression, bioreactor operations, and downstream purification. We generate recombinant proteins and novel therapeutic modalities to support internal programs across all stages of drug development. Our team is also responsible for the development and implementation of exciting new technologies around mammalian protein expression, bioreactor processing, product capture, polishing, and formulation of proteins and other therapeutic modalities. This role focuses on downstream purification at large-scale, having a hands-on laboratory role as part of a cross-functional team and being responsible for:
- Primary clarification using disk stack centrifuge and depth filters of bioreactors from 50-500L
- Recombinant protein purification using Bioprocess and AKTA pilot scale systems
- Development of polishing steps for purity enrichment
- Detailed production at scale prior to clinical manufacture
- Ultrafiltration / Diafiltration using bench and pilot scale systems
- Product and process characterization using SEC-HPLC, UV-VIS, Osmolarity device and other techniques
- Contributing to technology development projects to further develop in-house technologies
- Record all experiments accurately, clearly and in a timely fashion; prepare data summaries and appropriate reports according to project requirements and meeting required timelines.
- Presentation of data at informal group meetings for discussion and at departmental meetings.
- Actively contributing to the scientific direction of Biopharmaceutical Development (BPD) / Drug Substance Development Department.
- Implement and promote AstraZeneca's health and safety practices including the regulations governing COSHH, biological agents and genetically modified organisms as detailed in the relevant risk assessments.
Additional Responsibilities:
- You will play a significant role in supporting Tox supply activities and pilot scale for primary clarification, purification, and formulation of proteins.
- In addition, you will be involved in further development and improvement of the latest technologies.
- Liaising with both local and global colleagues across the business.
Qualifications:
- Relevant university degree (e.g., BSc/MSc/PhD) in Life Science, Chemical or Bioprocess Engineering, with relevant industrial experience desirable.
Knowledge & Skills:
- Technical and practical understanding of Protein purifications at 50-500L scale
- The use of Centrifuge and POD filtration as well as Bioprocess and AKTA pilot and associated software
Desirable Requirements:
- Experience of HPLC
- Experience of batch records
- Process filter sizing
- Experience large scale Tangential Flow Filtration
- Large scale column packing
- Experience in the use of data science and AI/ML tools for data analysis (DoE / foundation and agent-based AI assistants)
Behavioural Competencies:
- An adaptable team player and leader capable of working to tight deadlines and exacting standards.
- Enthusiastic, flexible and willing to learn.
- High level of attention to detail.
- Excellent communication skills.
- Good organisational and planning skills.
- Ability to effectively troubleshoot.
- Maintain good and consistent working relationships with all other members of the team and other AstraZeneca employees.
Senior Scientist (Large-Scale Purification) - 12-month FTC in Hartford employer: AstraZeneca UK Limited
Contact Detail:
AstraZeneca UK Limited Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Scientist (Large-Scale Purification) - 12-month FTC in Hartford
✨Tip Number 1
Network like a pro! Reach out to current employees at AstraZeneca or in the biopharmaceutical field. A friendly chat can give you insider info and maybe even a referral, which can really boost your chances.
✨Tip Number 2
Prepare for interviews by brushing up on your technical skills. Be ready to discuss your experience with protein purification and bioprocessing. We want to see your passion and expertise shine through!
✨Tip Number 3
Showcase your adaptability! In this role, you'll be part of a cross-functional team, so highlight your teamwork and problem-solving skills. Share examples of how you've tackled challenges in past projects.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen. Plus, it shows you’re serious about joining our awesome team at StudySmarter.
We think you need these skills to ace Senior Scientist (Large-Scale Purification) - 12-month FTC in Hartford
Some tips for your application 🫡
Tailor Your CV: Make sure your CV reflects the skills and experiences that match the Senior Scientist role. Highlight your relevant experience in protein purification and any hands-on laboratory work you've done. We want to see how you fit into our team!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about biopharmaceutical development and how your background aligns with our goals. Keep it engaging and personal – we love to see your personality come through!
Showcase Your Technical Skills: Be specific about your technical expertise, especially in large-scale purification processes and any relevant software you've used. Mention your experience with HPLC, centrifuges, and any data science tools. We’re keen on seeing how you can contribute to our exciting projects!
Apply Through Our Website: We encourage you to apply directly through our website for the best chance of getting noticed. It’s straightforward and ensures your application goes straight to us. Plus, you’ll find all the details you need about the role there!
How to prepare for a job interview at AstraZeneca UK Limited
✨Know Your Science
Make sure you brush up on your knowledge of protein purification techniques, especially at large scales. Be ready to discuss your hands-on experience with centrifuges, depth filters, and AKTA systems. This will show that you’re not just familiar with the theory but can apply it practically.
✨Showcase Your Team Spirit
Since this role involves working in a cross-functional team, be prepared to share examples of how you've collaborated with others in past projects. Highlight your adaptability and communication skills, as these are key to thriving in a dynamic environment like biopharmaceutical development.
✨Prepare for Technical Questions
Expect questions about specific techniques mentioned in the job description, such as ultrafiltration, diafiltration, and SEC-HPLC. Practise explaining these processes clearly and concisely, as well as any challenges you faced and how you overcame them.
✨Demonstrate Your Problem-Solving Skills
Be ready to discuss how you approach troubleshooting in the lab. Share specific examples where you identified a problem, analysed data, and implemented a solution. This will illustrate your analytical thinking and ability to maintain high standards under pressure.