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- Tasks: Lead innovative safety strategies for novel oncology therapies and collaborate with cross-functional teams.
- Company: Join a leading biotech firm dedicated to advancing oncology safety science.
- Benefits: Competitive salary, health benefits, and opportunities for professional growth.
- Why this job: Make a real impact in oncology by driving drug development and safety strategies.
- Qualifications: PhD or DABT in Toxicology or related fields with strong experience in Project Toxicology.
- Other info: Embrace a collaborative culture focused on inclusion and diversity.
The predicted salary is between 72000 - 108000 ÂŁ per year.
We are seeking a highly motivated and passionate Director, Project Toxicologist to join our OTD Safety group. This role focuses on novel targeted oncology therapies, including Radio Conjugates, Antibody Drug Conjugates (ADCs), and Small Molecules. While experience with Radio Conjugates is particularly valued, candidates with other modality expertise are encouraged to apply. You will partner with cross‑functional teams across Oncology R&D, bridging discovery and regulatory toxicology, driving innovative safety strategies, and accelerating drug development. Your expertise will inform candidate selection, guide regulatory strategy, and help define the future of oncology safety science.
Accountabilities
- Lead regulatory and investigative toxicology study design, developing strategies to predict, assess, and mitigate target‑and‑modality‑related safety risks.
- Apply your toxicology expertise to predict clinical safety risks and support data‑driven decisions across discovery and development programs.
- Innovate at the intersection of regulatory toxicology and cutting‑edge science, leveraging in vitro, in silico, in vivo, and emerging technologies like organ‑on‑chip, imaging, and omics.
- Communicate integrated risk assessments to governance bodies and contribute to regulatory submissions.
- Maintain and expand expertise in regulatory standards, preclinical safety, and modality‑specific safety science, staying ahead of industry trends.
- Provide strategic toxicology input for in‑licensing evaluations and external collaborations.
Qualifications
- Drive Oncology Safety science through internal and external collaborations, publications, and thought leadership.
- PhD and/or DABT in Toxicology, Pharmacology, Oncology, or related fields with a strong scientific track record.
- Strong prior experience in Project Toxicology, Investigative Toxicology, or related safety‑focused roles in pharma, biotech, or CRO environments.
- Or an advanced university degree accompanied by at least 10 years of relevant professional experience preferred, additional work experience in pharma industry in lieu of degree can be considered (ie. BSc with 15 yrs of experience).
- Minimum BSc degree with additional work experience in pharma industry required.
- Deep understanding of oncology drug discovery and development, with proven ability to deliver toxicology programs supporting IND filings.
- Expertise in Radio Conjugates or ADCs preferred, with familiarity in small molecule oncology therapeutics.
- Skilled in using in vitro, in silico, and in vivo tools to predict clinical safety risks.
- Collaborative, problem‑solving mindset with the ability to coordinate across multiple projects and geographies.
- Strong communication, interpersonal, and influencing skills to inform decisions across scientific and regulatory teams.
- Commitment to inclusion, diversity, and team development, supporting AstraZeneca's Great Place to Work objectives.
Director, Project Toxicologist - Oncology in Hartford employer: AstraZeneca UK Limited
Contact Detail:
AstraZeneca UK Limited Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Director, Project Toxicologist - Oncology in Hartford
✨Tip Number 1
Network like a pro! Reach out to professionals in the oncology field, especially those who work with Radio Conjugates or ADCs. Attend industry events or webinars to make connections and learn about potential job openings.
✨Tip Number 2
Show off your expertise! Prepare to discuss your experience in Project Toxicology and how it relates to the role. Be ready to share specific examples of how you've driven safety strategies in past projects.
✨Tip Number 3
Practice your pitch! When you get the chance to speak with hiring managers or recruiters, have a clear and concise summary of your background and what you can bring to the table. Confidence is key!
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets noticed. Plus, we love seeing candidates who are proactive about their job search.
We think you need these skills to ace Director, Project Toxicologist - Oncology in Hartford
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to highlight your experience in toxicology and oncology. We want to see how your background aligns with the specific requirements of the Director, Project Toxicologist role.
Craft a Compelling Cover Letter: Your cover letter should tell us why you're passionate about oncology and how your expertise can drive innovative safety strategies. Be sure to mention any relevant projects or experiences that showcase your skills.
Showcase Your Collaborative Spirit: Since this role involves working with cross-functional teams, highlight examples of successful collaborations in your application. We love seeing how you’ve partnered with others to achieve common goals.
Apply Through Our Website: Don’t forget to apply through our website! It’s the best way for us to receive your application and ensure it gets into the right hands. Plus, it shows you’re serious about joining our team.
How to prepare for a job interview at AstraZeneca UK Limited
✨Know Your Stuff
Make sure you brush up on your knowledge of oncology drug discovery and development, especially around Radio Conjugates and ADCs. Be ready to discuss how your past experiences align with the role's focus on innovative safety strategies.
✨Showcase Your Collaboration Skills
This role involves working with cross-functional teams, so be prepared to share examples of how you've successfully collaborated in the past. Highlight any experiences where you bridged gaps between different departments or contributed to team success.
✨Prepare for Technical Questions
Expect to dive deep into toxicology study design and risk assessment. Brush up on the latest regulatory standards and emerging technologies like organ-on-chip and omics, as these could come up during the interview.
✨Communicate Clearly
Strong communication skills are key for this position. Practice explaining complex scientific concepts in a straightforward way, as you'll need to convey integrated risk assessments to governance bodies and regulatory teams.