At a Glance
- Tasks: Design and validate assays for cutting-edge oncology drug development.
- Company: Join AstraZeneca, a leader in innovative bioscience research.
- Benefits: Competitive salary, comprehensive benefits, and a supportive work environment.
- Other info: Inclusive culture with opportunities for professional growth and collaboration.
- Why this job: Make a real impact in cancer treatment with advanced analytical techniques.
- Qualifications: Ph.D or M.Sc in relevant fields with hands-on experience in LC-MS and HPLC.
The predicted salary is between 60000 - 80000 £ per year.
AstraZeneca are seeking a highly skilled analytical scientist to work in our Oncology Targeted Delivery (OTD) team. Based at The Discovery Centre in Cambridge, you will be an integral member of the analytical team focusing on the rational design of assays involving biological matrices and analytical methods required to study linker payloads and antibody drug conjugates (ADCs). ADCs and related scaffold conjugates are among the fastest growing drug classes in oncology.
Responsibilities
- Independently design, execute and validate assays using LCMS techniques to monitor stability of small molecules and ADCs.
- Carry out studies to elucidate mechanistic insights relevant to ADC project biological results.
- Build and maintain state of the art MS & HPLC analytical methods for ADC and payload analysis and train others in their use and interpretation.
- Act as a subject matter expert as part of a multi‑disciplinary project team to support achievement of projects goals.
- Work independently within a team and collaboratively with internal and external stakeholders to ensure the efficient relay of information.
- Be involved in the interpretation of data with little or no guidance with a clear understanding of its implications within drug discovery and its ongoing utility for predictive modelling.
- Maintain a well‑developed understanding of analytical techniques, both internally and externally, as applying a broader functional knowledge to support the team.
- Regularly share relevant external published papers with peers.
- Perform routine HPLC‑MS based QC analysis of small molecules, ADCs and other types of biologic modalities.
- Ensure own work, and the work of others, is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Laboratory Practice (GLP).
Essential for the role
- Ph.D and/or M.Sc in Chemistry, Biochemistry or relevant Analytical Science discipline.
- B.Sc in above disciplines with extensive experience with LC‑MS, HPLC and assay development.
- Experience with QTOF or Orbitrap or relevant MS instruments.
- Hands‑on experience in bioanalysis and LC‑MS/MS for measurement of proteins, small molecules, and impurity profile identification.
- Experience in development and application of quantitative bioanalytical methods of proteins.
- Deep understanding of chemistry and protein biochemistry.
- Strong multi‑tasking, time management and organisational skills.
Desirable for the role
- Experience with other analytical technologies (e.g., SEC‑HPLC, HIC‑HPLC, CAD) and lab‑based automated liquid handlers.
- Experience with programming languages such as R, Python and familiarity with databases.
- Understanding the process of successful drug discovery/drug development.
- Experience with handling sample extraction from biological matrix and automated process set up.
- Experience with assay set up to monitor the stability of Linker payloads or ADCs in the presence of biologically relevant enzymes.
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
Senior Scientist (Analytical, Bioscience Category) in Cambridge employer: AstraZeneca GmbH
AstraZeneca is an exceptional employer located at the forefront of biomedical innovation in the Cambridge Biomedical Campus, offering a competitive salary package and comprehensive benefits. Our collaborative work culture fosters inclusivity and encourages professional growth, providing employees with opportunities to engage in cutting-edge research and development in oncology. Join us to be part of a dynamic team where your expertise will directly contribute to advancing life-changing therapies.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist (Analytical, Bioscience Category) in Cambridge
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We think you need these skills to ace Senior Scientist (Analytical, Bioscience Category) in Cambridge
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show AstraZeneca GmbH that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at AstraZeneca GmbH.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that AstraZeneca GmbH does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
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How to prepare for a job interview at AstraZeneca GmbH
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at AstraZeneca GmbH. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
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Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at AstraZeneca GmbH. This shows your passion for the industry!
