Research Scientist - In vitro display, Biologics discovery in Cambridge

Introduction to role:

We areseekinga highly motivated Research Scientist, Biologics Discovery - In Vitro Display to support our therapeutic discovery pipeline and contribute to the development of recombinant peptide andantibodiesdiscovery platforms.

The role will suit an organised and enthusiastic experimental scientist who can contribute to the design and execution of experiments, analyse and interpret data, and communicate findings clearly. Working collaboratively with colleagues across the Biologics Engineering group and broader project teams, the successful candidate will apply scientific curiosity and sound experimental practice to address biologics discovery challenges.

The role will involve the discovery, isolation, and optimisation of peptides and other biologics for therapeutic programmes using a range of in vitro display platforms, including phage, yeast, mRNA, and ribosome display.

This position offers the opportunity to developexpertisein peptide and antibody discovery, contribute to innovative biologics engineering approaches, and build experience within a collaborative, multidisciplinary drug discovery environment.

Education & Experience Requirements:

Graduate level scientist with hands-on laboratory-based experience.

Essential Skills/Experience:

• Experience ofbiologics/peptidehit identification and engineering using display technologies such asphage, yeast, mRNA, and ribosome displayincluding library design/generation, and selection campaigns using diverse enrichment strategies

• Hands-on experience in molecular biology methods and technologies (e.g., PCR, RT-PCR, cloning (ligation-dependent and independent methods), site-directed mutagenesis, Sanger sequencing/analysis, ideally applied to generation ofpeptide/antibodylibraries

• Experience with automation tosupportdiscovery efficiency, reproducibility, and throughput.

• Awareness ofAI, machine learning, and/or computational methods to therapeutic discovery in support of hit finding, sequence prioritisation or lead optimisation.

• Ability toapplyprotocols, troubleshoot, interpret experimental results/dataandmaintainaccurate, high quality and up-to-date experimental records

• Strong communicationskills in a team environment and an ability to learn and embracenew technologiesquickly

Desirable Skills/Experience:

• Experience of laboratory-based research in the pharmaceutical industry

• Experience with next-generation sequencing (NGS) applied to peptide/antibodydiscovery

• Ability to profilecompounds(e.g. SPR, BLI,biochemical assays)

• Experience in common expression systems (e.g. mammalian), purification methods (e.g.Aktasystems)

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca:

Here, your science moves with purpose. You will work with cutting-edge biotechnology, new drug modalities, and rich data to shape how serious diseases are treated, including opportunities at the earliest stages where impact is greatest. We bring diverse experts together to spark bold ideas, apply innovative methods like AI and novel selection strategies, and learn quickly from real evidence. We value kindness alongside ambition, empowering you to take smart risks, collaborate deeply, and see your discoveries turn into medicines that reach patients.

Date Posted 10-set.-2026

Closing Date 17-set.-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.