At a Glance
- Tasks: Lead innovative safety strategies in oncology drug development and collaborate with cross-functional teams.
- Company: AstraZeneca, a pioneering company dedicated to eliminating cancer as a cause of death.
- Benefits: Competitive salary, hybrid work model, and opportunities for professional growth.
- Other info: Join a diverse team committed to inclusion and ethical standards.
- Why this job: Make a real impact in cancer treatment and drive groundbreaking therapies to patients.
- Qualifications: DABT or PhD in toxicology/immunology with experience in non-clinical safety leadership.
The predicted salary is between 80000 - 100000 £ per year.
Location: Cambridge, UK (Hybrid, required 60% presence in the office)
Salary: Competitive
At AstraZeneca, our bold ambition is nothing less than to eliminate cancer as a cause of death. Our pioneering pipeline of oncology medicines reflects this mission, and our Immune Oncology (IO) Safety team plays a critical role in accelerating transformative therapies to patients. We are seeking a highly motivated, innovative, and passionate Director, Project Toxicologist, to join our IO Safety group. This role focuses on novel immunotherapeutics, including immune cell engagers. Candidates with a strong Immunology and toxicology background, preferably in Oncology, are encouraged to apply.
You will partner with cross-functional teams across Oncology R&D, bridging discovery and regulatory toxicology, Immunotoxicology, driving innovative safety strategies, and accelerating drug development. Your expertise will inform candidate selection, guide regulatory strategy, and help define the future of oncology safety science.
What You’ll Do
- As a core member of multi-disciplinary drug development teams, you will deliver globally acceptable toxicological packages to predict, assess and mitigate target and modality related safety risks to support data-driven decisions across discovery and development programs.
- You will develop and implement innovative solutions to combine regulatory toxicology with groundbreaking science and technologies to progress novel drug candidates to the clinic and through development to the market, in line with business needs.
- Influence project strategy and decision making, communicate clear positions on integrated risk assessments in various formats including informing internal decision-making governance bodies and interacting with external health authorities.
- Deliver quality non-clinical summaries and contribute to regulatory submissions for IO projects.
- Maintain and expand expertise in regulatory standards, preclinical safety, and modality-specific safety science, staying ahead of industry trends.
- Drive Oncology Safety science through internal and external collaborations, publications, and scientific leadership.
- Provide experienced non-clinical evaluation of in-licensing and out-licensing opportunities, mentorship and guidance to emerging toxicologists with respect to regulatory environment and supporting their career growth and development.
Education/Experience Requirements
- DABT or PhD in toxicology or immunology (or equivalent) with several years of experience in the pharmaceutical or biotechnology industry working as a non-clinical safety lead, supporting immunology and/or oncology programs with planning, execution, interpretation and communication of regulatory toxicology data.
- A proven understanding of drug discovery and development, with a track record of delivering multiple toxicology programs supporting IND/CTA filings.
- High level of knowledge and expertise in designing toxicology strategies and delivering in vitro/in vivo and risk assessment of immune/target related risks, driven by the pharmacology of IO therapeutics.
- Ability to solve problems in a goal-focused fashion with willingness to challenge conventional thinking and capacity to coordinate tasks across multiple projects and geographies.
- Excellent verbal and written communication, interpersonal- and influencing skills.
- Adopting an inclusive and collegiate working style, and a desire to drive own- and support others development.
- Represent AstraZeneca interests, maintaining high ethical and scientific standards.
- Commitment to inclusion and diversity, supporting AstraZeneca’s Great Place to Work objectives.
Dates
- Date Posted: 26-Jun-2026
- Closing Date: 12-Jul-2026
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
Director, Project Toxicologist – Immune Oncology (IO) Safety Science in Cambridge employer: AstraZeneca GmbH
AstraZeneca is an exceptional employer, dedicated to fostering a collaborative and inclusive work culture that empowers employees to drive innovation in the fight against cancer. Located in the vibrant city of Cambridge, UK, our hybrid work model promotes flexibility while ensuring meaningful engagement with cross-functional teams. We prioritise employee growth through mentorship opportunities and a commitment to professional development, making AstraZeneca a rewarding place for passionate individuals looking to make a significant impact in oncology safety science.
StudySmarter Expert Advice🤫
We think this is how you could land Director, Project Toxicologist – Immune Oncology (IO) Safety Science in Cambridge
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We think you need these skills to ace Director, Project Toxicologist – Immune Oncology (IO) Safety Science in Cambridge
Some tips for your application 🫡
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Make sure you brush up on key pharmaceutical concepts and recent developments in the industry. You might get asked some technical questions during the interview at AstraZeneca GmbH that show your grasp of drug development processes or regulatory requirements, so be ready to discuss them clearly.
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