At a Glance
- Tasks: Design and optimise crystallisation processes for API and key intermediate isolation.
- Company: Join Almac Sciences, a leader in innovative pharmaceutical solutions.
- Benefits: Enjoy professional development, attractive compensation, and a supportive work environment.
- Other info: Flexible working hours and excellent career growth opportunities await you.
- Why this job: Make a real impact in the pharmaceutical industry with cutting-edge crystallisation techniques.
- Qualifications: Degree in Chemistry or related field; experience in crystallisation process development required.
The predicted salary is between 40000 - 50000 £ per year.
The Crystallisation Process Scientist will be responsible for the design, development, and optimisation of crystallisation processes for API and key intermediate isolation and purification. The role involves applying fundamental understanding of solid-state chemistry, phase behaviour, and particle engineering to deliver robust, scalable crystallisation processes suitable for transfer to kilo lab, pilot and GMP manufacturing plants. Depending on your experience, you will provide technical leadership across projects, identifying and mitigating risks associated with crystallisation, solid form control, and downstream processing, while ensuring delivery to client timelines and regulatory expectations.
Key activities include:
- Design and execute crystallisation process development studies, including solvent selection, supersaturation control, and seeding strategies
- Develop robust crystallisation procedures for solid form control (polymorph, solvate, hydrate selection)
- Apply thermodynamic and kinetic principles to optimise nucleation, crystal growth, and particle size distribution
- Conduct solid-state and particle characterisation using appropriate analytical techniques (e.g., XRPD, DSC, microscopy)
- Define and control critical process parameters (CPPs) and critical material attributes (CMAs) related to crystallisation
- Support scale-up and technology transfer to pilot plant or kilo lab, ensuring process robustness and reproducibility
- Troubleshoot crystallisation challenges including oiling out, agglomeration, poor filtration, and polymorphic instability
- Collaborate with synthetic chemistry, analytical, and engineering teams to ensure integrated process understanding
- Maintain clear and compliant documentation aligned with GMP and CMC expectations
- Provide technical input for client discussions, reports, and regulatory documentation
Essential Candidate Criteria:
- Degree (or equivalent) in Chemistry, Chemical Engineering, or closely related discipline
- Demonstrated experience in crystallisation process development and solid-state chemistry
- Strong understanding of phase diagrams, solubility, and crystallisation kinetics
- Experience with scale-up considerations and process robustness in an industrial setting
- Proven ability to solve complex crystallisation and isolation challenges
Desirable Criteria:
- Postgraduate qualification (MSc/PhD) in Crystallisation, Solid-State Chemistry, or Particle Engineering
- Experience with PAT tools (e.g., FBRM, PVM) and advanced crystallisation monitoring
- Knowledge of polymorph screening and crystallisation risk management strategies
- Familiarity with GMP environments and regulatory expectations (CMC)
As part of a busy team within a rapidly growing organisation, operating within a challenging industry you will benefit from the numerous personal and professional developmental opportunities available throughout the Almac group.
Senior Crystallisation Process Development Chemist TLNT1_NI employer: Almac Group Ltd
Almac Sciences is an exceptional employer located in Craigavon, Northern Ireland, offering a dynamic work environment that fosters professional growth and development. With flexible working hours, a strong emphasis on employee recognition, and a comprehensive benefits package including healthcare and pension schemes, Almac is committed to supporting its staff in achieving their career aspirations while contributing to innovative projects in the pharmaceutical industry.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Crystallisation Process Development Chemist TLNT1_NI
✨Tip Number 1
Network like a pro! Reach out to your connections in the industry, attend relevant events, and engage with professionals on platforms like LinkedIn. We all know that sometimes it’s not just what you know, but who you know that can help you land that dream job.
✨Tip Number 2
Prepare for interviews by researching the company and the role thoroughly. Understand their projects, values, and recent developments. We want you to walk in feeling confident and ready to showcase how your skills align perfectly with their needs.
✨Tip Number 3
Practice makes perfect! Conduct mock interviews with friends or mentors to refine your answers and get comfortable discussing your experience. We believe that the more you practice, the more natural it will feel when it’s time to shine.
✨Tip Number 4
Don’t forget to follow up after your interview! A simple thank-you email can go a long way in leaving a positive impression. We recommend expressing your appreciation for the opportunity and reiterating your enthusiasm for the role.
We think you need these skills to ace Senior Crystallisation Process Development Chemist TLNT1_NI
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the Senior Crystallisation Process Development Chemist role. Highlight your experience in crystallisation process development and solid-state chemistry, as well as any relevant projects you've worked on. We want to see how your skills match what we're looking for!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you're passionate about this role and how your background makes you a great fit. Don’t forget to mention specific experiences that relate to the key activities listed in the job description.
Showcase Your Technical Skills:In your application, be sure to showcase your technical skills related to crystallisation processes, such as your understanding of phase diagrams and crystallisation kinetics. We love seeing candidates who can demonstrate their expertise in these areas!
Apply Through Our Website:We encourage you to apply through our website for the best chance of getting noticed. It’s super easy, and you’ll be able to keep track of your application status. Plus, we love seeing applications come directly from our site!
How to prepare for a job interview at Almac Group Ltd
✨Know Your Crystallisation Inside Out
Make sure you brush up on your knowledge of crystallisation processes, solid-state chemistry, and phase behaviour. Be ready to discuss specific examples from your past experience where you've successfully designed or optimised a crystallisation process.
✨Showcase Your Problem-Solving Skills
Prepare to talk about complex crystallisation challenges you've faced and how you tackled them. Think of scenarios involving oiling out, agglomeration, or polymorphic instability, and be ready to explain your thought process and the outcomes.
✨Familiarise Yourself with GMP Standards
Since this role involves working in a GMP environment, it’s crucial to understand the regulatory expectations. Brush up on your knowledge of GMP documentation and compliance, and be prepared to discuss how you’ve maintained these standards in previous roles.
✨Collaborate and Communicate
This position requires collaboration with various teams. Think of examples where you’ve worked cross-functionally, especially with synthetic chemistry or analytical teams. Highlight your communication skills and how they contributed to successful project outcomes.
