At a Glance
- Tasks: Join a cutting-edge research team to develop innovative human disease models.
- Company: University of Southampton, a leader in interdisciplinary research.
- Benefits: Competitive salary, world-class facilities, strong mentorship, and generous holiday allowance.
- Other info: Collaborative environment with opportunities for career growth and international collaboration.
- Why this job: Make a real impact in understanding complex diseases and advancing therapeutic discovery.
- Qualifications: PhD in relevant discipline with hands-on experience in stem cell and adipose tissue biology.
The predicted salary is between 36636 - 41064 £ per year.
We are seeking a highly motivated Postdoctoral Research Associate (PDRA) to join the MIMIC programme: “An interconnected multi‑organ platform to recreate the complex pathophysiology of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)”, a major UKRI-funded, interdisciplinary research initiative involving leading academic, clinical, and industrial partners across the UK, Europe, and the USA. MASLD is a complex multisystem metabolic disease involving pathological cross‑talk between the liver, adipose tissue, gut, and immune system. The MIMIC programme aims to develop human, immunocompetent, patient‑derived multi‑organ models, using induced pluripotent stem cells (iPSCs) and organ‑on‑chip technologies, to better understand disease mechanisms and accelerate therapeutic discovery.
This PDRA post focuses on the development and characterisation of iPSC‑derived adipose tissue models and their integration into multi‑tissue platforms.
The Role
The successful candidate will play a central role in contributing to the generation of biomimetic, immunocompetent adipose tissue constructs derived from human iPSCs. Working closely with stem cell biologists, immunologists, and bioengineers across the MIMIC consortium, the PDRA will:
- Develop and optimise iPSC‑derived adipocyte differentiation protocols
- Generate 3D adipose tissue organoids incorporating stromal, endothelial, and immune cell populations
- Perform in‑depth molecular, phenotypic and metabolic characterisation of adipose models
- Investigate inflammatory and metabolic dysfunction relevant to MASLD
- Contribute to multi‑organ integration, i.e. adipose–liver–gut cross‑talk
- Support benchmarking of in‑vitro findings against clinical and patient‑derived data
This role provides an exceptional opportunity to work at the cutting edge of human disease modelling, immunometabolism, and regenerative medicine within a large, well‑funded collaborative programme.
About you
You will hold a PhD/DPhil or equivalent in a relevant discipline along with:
- Strong hands‑on experience of stem cell-derived models
- Demonstrated expertise in adipose tissue biology and adipocyte differentiation
- Experience with 3D cell culture, organoid systems, or co‑culture models
- Solid grounding in molecular and cellular biology techniques
- Ability to work both independently and collaboratively within a large interdisciplinary programme
Informal enquiries are welcome and may be directed to: Jaswinder Sethi (j.sethi@soton.ac.uk). Please note that applications sent only to this email address will not be accepted.
What we offer
- An exciting post within a high‑profile UKRI‑funded research programme
- Access to world‑class facilities and international collaborators
- Strong mentorship and career development, including training and conference support
- Opportunities for collaboration, secondments, and interdisciplinary skills development
- A generous holiday allowance as well as additional university closure days
- A vibrant, inclusive, and supportive research environment
Proud member of the Disability Confident employer scheme.
3472226AF - Research Fellow in In Vitro Models of Human Disease in Southampton employer: Allscreens Nationwide Ltd
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StudySmarter Expert Advice🤫
We think this is how you could land 3472226AF - Research Fellow in In Vitro Models of Human Disease in Southampton
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We think you need these skills to ace 3472226AF - Research Fellow in In Vitro Models of Human Disease in Southampton
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Highlight Your Research Experience:When applying for a full-time role in scientific research, make sure to emphasise your research experience prominently in your CV. Share specific projects you’ve worked on, the methodologies you used, and any significant findings. If you’ve published papers or presented at conferences, definitely include that too – it shows you’re on it in the academic world!
Tailor Your Cover Letter to the Research Area:Your cover letter should reflect your passion for the specific area of research at Allscreens Nationwide Ltd. Mention relevant experiences that align with the organisation’s goals or projects. This shows that you’ve done your homework and are genuinely interested in the position – plus, it helps us see how you’d fit into the team dynamics.
Showcase Your Data Analysis Skills:In scientific research, data analysis skills are a big deal! Make sure to detail any relevant analytical tools or software you’re familiar with, like R, Python, or statistical packages. Employers are keen to know you can handle the data-heavy elements of the role, so add specific examples where you’ve used these skills effectively.
Discuss Your Future Research Goals:In your motivation section, it’s a great idea to talk about your future research goals and how they align with the work being done at Allscreens Nationwide Ltd. This shows that you’re not just looking for any job, but rather a chance to contribute meaningfully to the field. We love to see applicants who are forward-thinking and enthusiastic about their research journey!
How to prepare for a job interview at Allscreens Nationwide Ltd
✨Showcase Your Research Skills
In scientific research, it’s crucial to demonstrate your ability to design and conduct experiments. Come armed with examples of past projects where you've developed hypotheses, collected data, and analysed results. Be ready to discuss any specific methodologies or tools you’ve used, like PCR techniques or statistical software.
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