Molecular Histologist

Overview

GlaxoSmithKline (GSK) is a science-led global healthcare company with a special purpose: to help people do more, feel better, live longer. We are on an audacious journey to impact the health of 2.5 billion people over the next decade. Our R&D division is at the forefront of this mission, dedicated to the discovery and development of groundbreaking vaccines and medicines. We are transforming the landscape of medical research by integrating cutting-edge science and technology and harnessing the power of genetics and new data. By fostering a collaborative environment that unites the talents of our people, we are revolutionizing R&D to pre-empt and defeat diseases. Join us in our commitment to uniting science, technology, and talent to get ahead of disease together.

Key Responsibilities

• Apply histology techniques to animal and human tissue and develop assays for targets.
• Perform manual and automated platform optimisation/validation of IHC/IF antibody clones, dilutions, antigen retrieval and signal amplification technologies on both cryo and paraffin embedded human and animal tissues.
• Optimisation of ISH probe assays on both human and animal tissues. Developing & delivering low (2-6 plex) number multiplex immunohistochemistry/Immunofluorescence (IHC/IF), in situ hybridization (ISH) and co-localisation IHC/ISH protocols in support of Non-Clinical Histology.
• Support the use of digital whole slide scanning.
• Maintain timely communication to named key study personnel, other key stakeholders and management, of study related events and/or deviations.
• Work collaboratively with Discovery pathologists to identify project needs and develop tissue-based experiments to address project questions by agreed timelines.
• Work in partnership with project teams to understand project issues, provide input and report data to matrix teams, including close networking with all imaging groups across GSK. Apply broad knowledge of science, drug discovery and histology/ molecular assays to guide experimental designs that deliver the best possible science.
• Adopt and routinely apply other tissue-based assay technologies as they become embedded within the histology community.
• Present molecular histology data to project teams.
• Share responsibility for lab management, equipment maintenance, safety and similar roles.

Experience, Skills & Qualifications

• Manual IHC experience.
• Immunohistochemistry (ISC) experience.
• InSituHybrdization (ISH) experience.
• Experience with automated instruments – Roche Ultra and Leica BOND RX.
• Histology skills, tissue trimming, processing, embedding, and microtomy.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

Inclusion at GSK

GSK is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

If you need any adjustments in the recruitment process, please get in touch with our Recruitment team (EMEA-GSKLink@allegisglobalsolutions.com) to further discuss this today.

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