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- Tasks: Lead market access strategies for rare disease therapies and engage with key stakeholders.
- Company: Join a leading biopharmaceutical company dedicated to innovative therapies for rare diseases.
- Benefits: Competitive salary, excellent benefits, and opportunities for professional growth.
- Why this job: Make a real difference in patient access to life-changing treatments for rare conditions.
- Qualifications: Bachelor's degree in Life Science and experience in HTA and market access.
- Other info: Dynamic role with cross-functional collaboration and impactful projects.
The predicted salary is between 70000 - 90000 ÂŁ per year.
Location: London, UK
Competitive Salary & Excellent Company Benefits
We are seeking a Senior Market Access Manager to lead Health Technology Appraisal (HTA) and Pricing engagements for selected rare disease assets and indications across the UK and Ireland. You will generate highâquality national, regional and local access strategies, develop robust evidence submissions, and secure pricing business case approvals that unlock timely patient access to innovative therapies.
This role sits at the heart of our rare disease portfolio, partnering across medical affairs, corporate affairs, commercial and global functions to shape and deliver access strategies that maximise asset value and impact for patients living with rare conditions.
What You'll Do
- HTA strategy and delivery (c.60%)
- Lead the UK/I market access strategy for selected rare disease assets, collaborating across global and local teams.
- Develop highâquality HTA submissions and other national submissions, managing external suppliers as needed.
- Own productâlevel engagements with HTA bodies (NICE, SMC, AWMSG, NCPE), including scientific advice and system engagement meetings.
- Serve as the UK subjectâmatter expert on market access to inform optimal HTA strategies and pipeline commercialisation plans.
- Contribute to lifecycle planning by shaping market access strategies that support launch and sustained uptake.
- Pricing strategy and process management (c.20%)
- Lead UK/I pricing strategy for assigned rare disease assets and develop innovative pricing approaches suited to small populations and specialised commissioning.
- Build and secure internal pricing business cases; manage inputs to commercial access agreements (e.g., PAS, tenders).
- Collaborate with New Product Planning to maintain accurate UK Pharmascan entries for pipeline products.
- External engagement and advocacy (c.20%)
- Act as a subjectâmatter expert on national and regional access and funding pathways.
- Engage national, regional and local stakeholders to improve the access environment in partnership with Corporate Affairs.
- Represent the organisation at relevant conferences (e.g., NICE Conference, ISPOR) to gather insights and anticipate opportunities.
- Translate national decisions into local context by communicating evolving system dynamics and implications for access.
Essential Qualifications
- Bachelor's degree in Life Science or closely related discipline.
- Formal training or demonstrated proficiency in HTA and UK market access frameworks (NICE, SMC, AWMSG, NCPE).
- Strong understanding of specialised/highly specialised commissioning in the UK (NHSE) and orphan/ultraâorphan access pathways.
Essential Experience
- Experience leading and delivering successful HTA submissions for rare disease therapies.
- Proven track record developing and executing pricing and access strategies, securing internal pricing approvals, and managing commercial access agreements (e.g., PAS).
- Strong external engagement with national agencies and payers; effective participation in advice meetings, consultations and system forums.
- Leadership of HTA submissions (NICE/SMC/AWMSG/NCPE), including coâleading evidence generation with health economists and managing external suppliers, with successful outcomes for highâcost, specialised/rare/orphan assets.
- Experience partnering with specialised centres, clinical networks and patient organisations to inform access strategy and evidence positioning.
- Exceptional project management, delivering crossâfunctional submissions and launchâcritical milestones on time.
- Fluent English with excellent written and verbal communication across technical and executive audiences.
Skills And Capabilities
- Strategic mindset and technical depth: designs optimal HTA and pricing/access pathways; understands funding flows and stakeholder dynamics across UK & Ireland in the context of rare diseases.
- Results orientation and accountability: delivers complex submissions and pricing approvals to plan; sets and manages clear KPIs.
- External influence and network building: credible engagement with HTA bodies, payers and policy stakeholders to enable timely, positive decisions.
- Communication excellence: synthesises complex evidence and policy into clear recommendations; produces highâquality submission content and executive briefs.
- Rare disease acumen: articulates compelling value propositions, addresses smallâpopulation evidence challenges (heterogeneity, RWE), and navigates specialised commissioning.
- Crossâfunctional leadership: orchestrates multiâdisciplinary teams, resolves ambiguity and drives clarity in a matrix.
- Integrity and judgement: applies governance rigour and risk management across HTA, pricing and external engagements.
Desirable strengths: negotiation and commercial acumen; analytical fluency with models and RWE; future scanning of HTA and policy; familiarity with international orphan frameworks; AI literacy to streamline HTA and submission processes.
Interested? Please submit your CV by COB 7th April 2026.
Date Posted 18-Mar-2026
Closing Date 06-Apr-2026
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
Senior Market Access Manager - Rare Disease in London employer: Alexion Pharmaceuticals, Inc.
Contact Detail:
Alexion Pharmaceuticals, Inc. Recruiting Team
StudySmarter Expert Advice đ¤Ť
We think this is how you could land Senior Market Access Manager - Rare Disease in London
â¨Tip Number 1
Network like a pro! Reach out to industry contacts on LinkedIn or at conferences. We all know that sometimes itâs not just what you know, but who you know that can get you in the door.
â¨Tip Number 2
Prepare for interviews by researching the company and its rare disease portfolio. We want to see your passion and knowledge shine through, so be ready to discuss how you can contribute to their market access strategies.
â¨Tip Number 3
Practice your pitch! We recommend rehearsing answers to common interview questions, especially around HTA submissions and pricing strategies. The more confident you are, the better youâll perform.
â¨Tip Number 4
Donât forget to follow up after interviews! A quick thank-you email can go a long way. It shows your enthusiasm and keeps you fresh in their minds. And remember, apply through our website for the best chance!
We think you need these skills to ace Senior Market Access Manager - Rare Disease in London
Some tips for your application đŤĄ
Tailor Your CV: Make sure your CV is tailored to the Senior Market Access Manager role. Highlight your experience with HTA submissions and pricing strategies, especially in rare diseases. We want to see how your background aligns with what we're looking for!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about market access in rare diseases and how your skills can contribute to our mission. Keep it engaging and relevant to the job description.
Showcase Your Achievements: When detailing your experience, focus on specific achievements that demonstrate your success in leading HTA submissions and securing pricing approvals. Numbers and outcomes speak volumes, so donât hold back!
Apply Through Our Website: We encourage you to apply through our website for a smoother application process. It helps us keep track of your application and ensures you donât miss any important updates from us. Plus, itâs super easy!
How to prepare for a job interview at Alexion Pharmaceuticals, Inc.
â¨Know Your HTA Inside Out
Make sure youâre well-versed in the Health Technology Appraisal (HTA) processes, especially those relevant to rare diseases. Brush up on NICE, SMC, AWMSG, and NCPE frameworks, as these will likely come up during your interview. Being able to discuss specific examples of successful submissions will really impress.
â¨Showcase Your Strategic Mindset
Prepare to discuss how youâve developed and executed market access strategies in the past. Think about specific challenges you faced and how you overcame them. This role requires a strategic approach, so demonstrating your ability to think critically and plan effectively will be key.
â¨Engage with Real-World Evidence
Familiarise yourself with real-world evidence (RWE) and how it applies to rare disease therapies. Be ready to talk about how youâve used RWE to support pricing and access strategies. This shows that you understand the complexities of small populations and can navigate the evidence landscape.
â¨Build Your External Engagement Stories
Think of examples where youâve successfully engaged with national agencies, payers, or patient organisations. Prepare to share how these interactions influenced access strategies or improved the environment for rare disease therapies. Strong external influence is crucial for this role, so highlight your networking skills.