Bioanalytical Scientist in Whittlesford

Alchemab Therapeutics is an exciting, big ambition, fast‑paced antibody therapeutics company using the power of the human immune system to discover the next targets and therapies for hard‑to‑treat diseases. The company brings together cutting‑edge technologies, including antibody repertoire profiling, deep learning and proteomics and world‑leading expert founders and management team. Alchemab is initially focused on the areas of neuroscience and oncology. Founded in 2019, Alchemab aims to deliver a pipeline of targets and therapeutic candidates moving into development phases from 2023 and beyond. We share the bold ambition to be a transformational large molecule therapeutics company with a broad pipeline of internal and partnered novel targets & candidates. The company has its headquarters in London and research activities in Cambridge, UK.

The Role

Reporting to the Director of Bioanalysis, we are seeking a highly motivated and skilled Large Molecule Bioanalytical Scientist who will work within a broader translational team and contribute to non‑clinical and clinical development activities. The role will focus on aligning with internal stakeholders and external service providers to collaborate on effective bioassay delivery goals. You will be instrumental in designing, developing, and characterising assays in a timely fashion to support the pharmacokinetics, pharmacodynamics, and immunogenicity assessment of our novel antibody therapeutics. This is a hands‑on, lab‑based role.

Responsibilities

• Develop, optimise, and partially validate robust and phase‑appropriate bioanalytical methods using suitable immunoassay technologies for quantifying antibody drugs, and biomarkers in various biological matrices (e.g., plasma/serum, urine, tissues).
• Ensure successful transfer of bioanalytical assays to external CROs.
• Conduct sample analysis for non‑regulated study phases, as required, ensuring high‑quality, reproducible data.
• Maintain detailed records of experiments, protocols, and results, and perform data analysis & interpretation, applying statistical methods to ensure data accuracy and reliability.
• Troubleshoot method and instrumentation issues effectively.
• Collaborate closely with early discovery and development teams.
• Communicate efficiently, interpret and summarise data for presentation to different audiences.
• Maintain assigned laboratory equipment and/or duties.
• Perform all work demonstrating due care and attention to all health and safety and COSHH regulations, and Human Tissue Act records where required.

Required Qualifications

• Bachelor’s degree in Biochemistry, or a closely related field within biology or analytical sciences.

Required Experience

• Demonstrable bioanalytical experience in a drug discovery and development context.
• Experience with development and validation of a variety of different assay formats.
• Proven hands‑on experience with immunoassay techniques such as ELISA, MSD, Gyrolab.
• Good understanding of GxP and current FDA/EMA bioanalytical regulatory guidelines.
• Excellent organisational and communication (written and verbal) skills and a pro‑active approach to problem‑solving.
• Ability to work independently and as part of a multi‑disciplinary team.

Desirable Skills

• LC‑MS/MS LIMS and electronic lab notebooks (ELN).
• Method transfer and managing external CROs.
• Cell based assays.

NOTE: This job description is not intended to be all‑inclusive. Employees may perform other related duties as negotiated to meet the ongoing needs of the organisation.