Senior Scientist, Multispecific Antibody Engineering (Oncology) in Worcester

AbbVie’s Discovery Biotherapeutics team is seeking a Senior Scientist to design, engineer, and manufacture multispecific biologics, primarily supporting oncology programs. The role requires extensive experience with biologics production platforms, analytical characterization, and a proven record of implementing multispecific engineering and production strategies.

Key Responsibilities

• Design, engineer, and produce multispecific biologics to support oncology initiatives.
• Integrate state‑of‑the‑art technologies to improve therapeutic production platforms and solve technical challenges with creative, “out‑of‑the‑box” thinking.
• Serve as the Multispecifics Engineering representative for cross‑functional teams, providing scientific insights across multiple therapeutic areas and recognised expertise in multispecific design and production.
• Lead biologics coordination on projects, managing activities from hit generation through candidate nomination.
• Identify and solve technical problems independently, conceiving and implementing innovative process research ideas.
• Ensure consistency and quality of technical reports.
• Provide project updates, analyses, and advice to cross‑functional teams and senior management.
• Present original work internally and at external scientific conferences; author or co‑author peer‑reviewed scientific papers or patents.

Qualifications

• PhD, MS, or BS in Biochemistry, Biochemical Engineering, or related discipline; 0–5 (PhD), 8–11 (MS), or 10–13 (BS) years of experience, ideally in multispecific biologics engineering.
• Extensive experience with protein, biologics, fragments, and multispecific design, expression, and purification.
• Design experience of multispecifics for ADC preferred.
• Experience with purification and automation instruments (e.g., Akta, Kingfisher, Hamilton).
• Strong scientific understanding of current protein expression, separation, and analytical technologies; ability to develop new purification approaches.
• Experience with CRO coordination and in‑vitro analytical techniques (SEC, MS, DSF); developability screening for multispecifics preferred.
• Strong molecular biology skills (molecular cloning) and sequence analysis tools (Vector NTI, Geneious, Genedata).
• Knowledge of biologic pipeline progression from exploratory through candidate nomination; program management experience preferred.
• Excellent organisational skills, ability to manage multiple projects simultaneously and adapt to rapid change in priorities.
• Goal‑oriented team player with strong verbal and written communication skills; strong can‑do attitude.
• Recognised in the scientific community through a sustained record of peer‑reviewed publications and patents preferred.

Key AbbVie Competencies

• Builds strong relationships with peers and cross‑functional partners.
• Learns fast, grasps the “essence” and can change direction quickly where indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces ideas of others, nurtures innovation, and manages innovation to reality.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, and serving our community.