AAVantgarde is a clinical-stage biotechnology company advancing best-in-class therapies for patients with inherited retinal diseases. The company's lead programs target Stargardt disease and retinitis pigmentosa due to Usher syndrome type 1B - two severe inherited retinal diseases with no approved treatments. With a strong foundation in translational science and a commitment to clinical excellence, AAVantgarde is working to bring transformative therapies to patients.
About the Role
A senior, hands-on statistical role within Biometrics. The Director will personally lead statistical strategy and execution on assigned ophthalmology studies and contribute to cross-programme methodology and innovation. Technical leadership and hands-on delivery are at the heart of the role. Close partnership with Clinical Development, Regulatory, Data Management, and Statistical Programming is essential.
Responsibilities
- Act as lead statistician end-to-end on assigned studies, personally driving design, analysis, and interpretation.
- Author statistical sections of protocols, SAPs, and regulatory documents, including estimand framework, sample size, and analysis methodology.
- Hands-on application of MMRM, mixed models, longitudinal analyses, multiple imputation, and Bayesian approaches where justified.
- Design and interpret sensitivity and supplementary analyses aligned with ICH E9(R1).
- Perform and QC statistical analyses directly; review outputs at code and dataset level as needed.
- Support health authority interactions and author statistical content for briefing documents.
- Oversee CRO/FSP statistical deliverables from a technical standpoint.
- Champion modern statistical computing (SAS, R, Python) and AI-enabled analytics.
Qualifications
- PhD in Statistics or Biostatistics preferred; MSc with equivalent experience considered.
- Significant and proven biostatistics experience in pharma, biotech, or CRO.
- Demonstrated lead-statistician experience, ideally including ophthalmology or a therapeutic area with imaging- and function-based endpoints.
- Deep fluency in ICH E9 / E9(R1), longitudinal methods, missing-data approaches, and multiplicity control.
- Strong hands-on proficiency in SAS and R; familiarity with modern data platforms a plus.
Attributes
Rigorous, pragmatic, delivery-focused, and patient-centred. A hands-on doer who enjoys being close to the data and the methodology. A clear communicator, curious about new methods and tools, and committed to the highest standards of scientific quality.
Compensation
Compensation will be a competitive salary, share options, pension and target bonus
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Director of Biostatistics employer: Aavantgarde
AAVantgarde is an exceptional employer, offering a dynamic work environment in the heart of London where innovation meets clinical excellence. With a strong emphasis on employee growth and collaboration, we provide opportunities for professional development in cutting-edge gene therapy strategies while maintaining high ethical standards. Join us to be part of a team that values your expertise and fosters a culture of inclusivity and advancement in the field of ophthalmology.
