At a Glance
- Tasks: Lead statistical strategy and execution on ophthalmology studies with hands-on delivery.
- Company: AAVantgarde, a collaborative and inclusive environment in the biostatistics field.
- Benefits: Competitive salary, professional development, and a commitment to equal opportunities.
- Other info: Join a dynamic team focused on scientific quality and modern statistical computing.
- Why this job: Make a real impact in healthcare by driving innovative statistical methodologies.
- Qualifications: PhD or MSc in Statistics/Biostatistics with significant experience in pharma or biotech.
The predicted salary is between 54000 - 66000 £ per year.
About the Role
A senior, hands-on statistical role within Biometrics.
The Director will personally lead statistical strategy and execution on assigned ophthalmology studies and contribute to cross-programme methodology and innovation.
Technical leadership and hands-on delivery are at the heart of the role.
Close partnership with Clinical Development, Regulatory, Data Management, and Statistical Programming is essential.
Responsibilities
- Act as lead statistician end-to-end on assigned studies, personally driving design, analysis, and interpretation.
- Author statistical sections of protocols, SAPs, and regulatory documents, including estimand framework, sample size, and analysis methodology.
- Hands-on application of MMRM, mixed models, longitudinal analyses, multiple imputation, and Bayesian approaches where justified.
- Design and interpret sensitivity and supplementary analyses aligned with ICH E9(R1).
- Perform and QC statistical analyses directly; review outputs at code and dataset level as needed.
- Support health authority interactions and author statistical content for briefing documents.
- Oversee CRO/FSP statistical deliverables from a technical standpoint.
- Champion modern statistical computing (SAS, R, Python) and AI-enabled analytics.
Qualifications
- Ph D in Statistics or Biostatistics preferred; MSc with equivalent experience considered.
- Significant and proven biostatistics experience in pharma, biotech, or CRO.
- Demonstrated lead-statistician experience, ideally including ophthalmology or a therapeutic area with imaging- and function-based endpoints.
- Deep fluency in ICH E9 / E9(R1), longitudinal methods, missing-data approaches, and multiplicity control.
- Strong hands-on proficiency in SAS and R; familiarity with modern data platforms a plus.
- Attributes
Rigorous, pragmatic, delivery-focused, and patient-centred.
A hands‑on doer who enjoys being close to the data and the methodology.
A clear communicator, curious about new methods and tools, and committed to the highest standards of scientific quality.
Equal Opportunities
At AAVantgarde, we are committed to fostering a welcoming, collaborative, and inclusive environment.
We believe in providing equal opportunities for all and do not discriminate on the basis of race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, or any other legally protected characteristics.
All applicants will receive equal consideration for employment.
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Director of Biostatistics in London employer: AAVantgarde Bio
AAVantgarde is an exceptional employer for the Director of Biostatistics role, offering a dynamic and collaborative work culture that prioritises innovation in ophthalmology studies. Employees benefit from hands-on involvement in cutting-edge statistical methodologies, alongside opportunities for professional growth and development within a supportive environment that values diversity and inclusion. Located in a vibrant area, AAVantgarde fosters a strong sense of community, making it an ideal place for those seeking meaningful and rewarding careers in biostatistics.
