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- Tasks: Lead innovative projects in enzymology and biochemistry to tackle cancer targets.
- Company: Join a cutting-edge organisation dedicated to advancing drug discovery and oncology research.
- Benefits: Enjoy a permanent position with opportunities for professional growth and collaboration.
- Why this job: Make a real impact in cancer research while working with top scientists in the field.
- Qualifications: PhD in Enzymology or Pharmacology with significant experience in drug discovery required.
- Other info: Be part of a dynamic team that values creativity and scientific excellence.
The predicted salary is between 48000 - 72000 ÂŁ per year.
Principal Scientist (2‑Year Contract) Location: Jealott’s Hill, Bracknell Contract Length: 2 years Pay Rate: £23.89 per hour Industry: Leading AgriTech and Chemical Research Organisation We are seeking an experienced Principal Scientist to join a world‑class research team at the Jealott’s Hill International Research Centre. This is an excellent opportunity to contribute to cutting‑edge discovery, process development, and biotechnology innovation within a leading science‑based organisation. This two‑year contract role will see you working within a multidisciplinary environment, supporting key programmes that drive the advancement of agricultural and biological sciences. About the Role As a Principal Scientist, you will be responsible for shaping and directing upstream process development strategies. Your work will influence a wide range of research activities and contribute to improvements across multiple scientific projects. Key responsibilities include: Leading upstream process development for recombinant protein production. Providing scientific leadership and mentorship to project teams. Translating expression optimisation from shake flask formats into bioreactors. Designing and improving expression methods to maximise protein quality. Investigating how expression conditions affect protein quality attributes. Collaborating across functional teams to deliver data‑driven process improvements. Ensuring compliance with health, safety, and environmental policies. Essential Experience Post‑Doctoral (or equivalent) background in Biotechnology, Microbiology, or related disciplines. 8+ years’ experience in upstream bioprocessing. Strong expertise in recombinant protein expression (bacterial, insect, yeast, or plant systems). Hands‑on experience with bioreactors and scaling processes from shake flask to reactor. Good understanding of protein purification techniques. Proven troubleshooting and innovative problem‑solving abilities. Understanding of how upstream decisions impact downstream processing. Strong communication skills and ability to present complex scientific information clearly. Desirable Experience Knowledge of construct design and its impact on expression. Experience applying AI or computational tools to experimental design. Familiarity with Design of Experiments (DoE) approaches. Experience with Ambr250 micro‑bioreactor systems. Background in protein characterisation. Experience with scalable bioprocess technologies such as TFF. Industry experience within Biopharma, AgriTech, or related sectors.
Principal Scientist employer: SRG
Contact Detail:
SRG Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Principal Scientist
✨Tip Number 1
Network with professionals in the enzymology and drug discovery fields. Attend relevant conferences and seminars to meet potential colleagues and industry leaders, as this can help you gain insights into the latest trends and opportunities.
✨Tip Number 2
Engage with online communities and forums related to enzymology and biochemistry. Sharing your knowledge and experiences can help you build a reputation and connect with others who may know about job openings.
✨Tip Number 3
Consider reaching out to current or former employees of StudySmarter or similar companies. Informational interviews can provide valuable insights into the company culture and expectations for the Principal Scientist role.
✨Tip Number 4
Stay updated on the latest research and advancements in enzymology and drug discovery. Being knowledgeable about recent developments will not only enhance your expertise but also demonstrate your passion for the field during interviews.
We think you need these skills to ace Principal Scientist
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your expertise in enzymology and biochemistry. Focus on relevant experiences, particularly those related to drug discovery and biochemical assay development.
Craft a Compelling Cover Letter: Write a cover letter that showcases your passion for the role and the impact you can make. Mention specific projects or achievements that demonstrate your scientific leadership and experience in characterising cancer targets.
Highlight Relevant Skills: In your application, emphasise your understanding of steady-state and pre-steady-state enzymology, as well as any experience with modelling and simulation. This will show that you meet the job requirements.
Showcase Your Network: If applicable, mention your external reputation in enzymology, including any presentations at key conferences or publications. This can help establish your credibility and fit for the role.
How to prepare for a job interview at SRG
✨Showcase Your Expertise
Make sure to highlight your deep knowledge of enzymology and biochemistry during the interview. Prepare specific examples of past projects where you successfully designed biochemical assays or characterised cancer targets, as this will demonstrate your capability and experience.
✨Discuss Leadership Experience
Since the role requires scientific leadership, be ready to discuss your experience in managing teams and projects. Share instances where you prioritised work effectively and delivered team objectives on time, showcasing your ability to lead and inspire others.
✨Prepare for Technical Questions
Expect technical questions related to steady-state and pre-steady-state enzymology, as well as biochemical assay development. Brush up on these topics and be prepared to explain complex concepts clearly, demonstrating your theoretical and practical understanding.
✨Network and Reputation
Given the importance of having a strong external reputation, be prepared to discuss your professional network and any relevant presentations or publications. This can help establish your credibility and show that you are well-connected in the field of enzymology.
