Senior Scientist (Next-generation sequencing) - Generative Biology Institute
Senior Scientist (Next-generation sequencing) - Generative Biology Institute

Senior Scientist (Next-generation sequencing) - Generative Biology Institute

Oxford Full-Time 48000 - 72000 £ / year (est.) No home office possible
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At a Glance

  • Tasks: Join our team to design and execute cutting-edge sequencing workflows.
  • Company: The Ellison Institute of Technology tackles global challenges through innovative science and technology.
  • Benefits: Enjoy competitive salary, enhanced holiday pay, private medical insurance, and more perks.
  • Why this job: Be part of a collaborative culture that values creativity and makes a real-world impact.
  • Qualifications: PhD or equivalent experience in genomics or related fields; hands-on sequencing experience required.
  • Other info: Must be eligible to work in the UK and willing to travel as needed.

The predicted salary is between 48000 - 72000 £ per year.

Senior Scientist (Next-generation sequencing) – Generative Biology Institute

Senior Scientist (Next-generation sequencing) – Generative Biology Institute

The Ellison Institute of Technology (EIT) tackles humanity\’s greatest challenges by turning science and technology into impactful global solutions. Focused on areas like health, food security, sustainable agriculture, climate change, clean energy, and robotics in an era of artificial intelligence. EIT blends groundbreaking research with practical applications to deliver lasting results.
A cornerstone of EIT mission is its upcoming 300,000-square-foot research facility at the Oxford Science Park, set to open in 2027. This cutting-edge campus will feature advanced labs, an oncology and preventative care clinic, and collaborative spaces to strengthen its partnership with the University of Oxford. It will also host the Ellison Scholars, driving innovation for societal benefit.
The Generative Biology Institute (GBI) at the Ellison Institute of Technology (EIT) aims to overcome two major challenges in making biology engineerable: 1) the ability to precisely synthesize entire genomes, and 2) understanding which DNA sequences will create biological systems that perform desired functions. Solving these challenges will unlock the potential of biology for transformative solutions in health, sustainability, agriculture, and more. GBI will house 30 groups and over 300 researchers, supported by cutting-edge facilities and sustained funding to address global challenges and advance biology engineering.
EIT fosters a culture of collaboration, innovation, and resilience, valuing diverse expertise to drive sustainable solutions to humanity\’s enduring challenges.
Job Summary:
We are seeking a highly motivated scientist to join as a founding member of our next-generation sequencing team within a dynamic research environment. Overall, this team will empower fellow scientists to confidently take full advantage of next-generation sequencing technology in their research.
This team will manage the walk-up and supervised usage of Illumina, Nanopore, PacBio & Elements sequencing machines, be assisted by a state-of-the-art automation platform, and have access to a high-performance cluster for bioinformatic analysis.
The successful candidate will play a key role in supporting research across multiple groups and themes by providing expertise in delivering high-quality sequencing data and developing innovative workflows that support a diversity of experimental applications. You will collaborate closely with research groups to design and execute sequencing strategies tailored to novel and emerging scientific questions, and such contributions will be equitably acknowledged through authorship on relevant outputs.
Key Responsibilities:

  • To design and perform sequencing workflows using a range of platforms (Illumina, Oxford Nanopore, PacBio and Elements) or other high-throughput platforms, adapting protocols as needed to meet experimental requirements
  • To design and execute bespoke sequencing experiments, collaborating with research teams working across niche and novel synthetic, molecular & cell biology applications
  • To train, assist and feedback to other scientists who can or wish to utilise next-generation sequencing in a walk-up fashion.
  • To analyse sequencing data using existing bioinformatics tools and pipelines, and bespoke solutions if necessary, delivering actionable insights to collaborating scientists
  • To continuously curate an expert understanding on the underlying technologies in the full sequencing workflow (Experiment – DNA extraction – library preparation – sequencing – analysis, and associated QC steps).
  • To have a close working relationship with scientists from automation and bioinformatics teams.
  • To contribute to the maintenance, calibration, and troubleshooting of sequencing instruments, ensuring maximal performance and data quality
  • To stay abreast of new sequencing technologies and methodologies, integrating improvements to enhance performance, throughput and cost-efficiency

Requirements
Essential Knowledge, Skills and Experience:

  • A PhD (or equivalent industry experience) in a relevant field, such as genomics, molecular biology, synthetic biology, cell biology, or computational biology
  • Hands-on experience with next-generation sequencing technologies (e.g., Illumina, Oxford Nanopore)
  • Proven ability to develop, adapt, and troubleshoot sequencing workflows
  • Familiarity with basic bioinformatics tools for sequencing analysis and interpretation OR confident in multiple programming languages and coding/simple software development
  • A track record of working effectively in a collaborative, multi-disciplinary research environment
  • Exceptional communication skills: possess a desire to understand the scientific requests of collaborators in depth, manage multiple continuous collaborations, and translate complex concepts and data interpretation into clear, actionable outputs for non-specialists.

Desirable:

  • Experience with LIMS, ELNs and data management
  • Experience in biological library screening, e.g. directed evolution, CRISPR screening, display technologies, deep mutational scanning.
  • Experience with advanced sequencing techniques such as Hi-C, ChIP-Seq, SHAPE, nascent RNASeq
  • Experience in bioinformatics packages such as Nextflow, GATK, hifiasm
  • Experience with common programming languages such as Python, R, Unix
  • Experience with laboratory automation (e.g. Biomek i7)

Benefits
We offer the following salary and benefits:

  • Salary: Competitive salary on offer
  • Enhanced holiday pay
  • Pension
  • Life Assurance
  • Income Protection
  • Private Medical Insurance
  • Hospital Cash Plan
  • Therapy Services
  • Perk Box
  • Electrical Car Scheme

Why work for EIT:
At the Ellison Institute, we believe a collaborative, inclusive team is key to our success. We are building a supportive environment where creative risks are encouraged, and everyone feels heard. Valuing emotional intelligence, empathy, respect, and resilience, we encourage people to be curious and to have a shared commitment to excellence. Join us and make an impact!
Terms of Appointment:

  • You must have the right to work permanently in the UK with a willingness to travel as necessary
  • You will live in, or within easy commuting distance of, Oxford
  • During peak periods, some longer hours may be required and some working across multiple time zones due to the global nature of the programme

Seniority level

  • Seniority level

    Mid-Senior level

Employment type

  • Employment type

    Full-time

Job function

  • Job function

    Science

  • Industries

    IT Services and IT Consulting

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Senior Scientist (Next-generation sequencing) - Generative Biology Institute employer: Ellison Institute of Technology Oxford

The Ellison Institute of Technology (EIT) is an exceptional employer, fostering a collaborative and inclusive work culture that values creativity and diverse expertise. Located at the innovative Oxford Science Park, EIT offers cutting-edge facilities and ample opportunities for professional growth, allowing employees to contribute to impactful global solutions in health, sustainability, and technology. With competitive benefits and a commitment to employee well-being, EIT is dedicated to making a meaningful difference while supporting its team members' aspirations.
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Contact Detail:

Ellison Institute of Technology Oxford Recruiting Team

StudySmarter Expert Advice 🤫

We think this is how you could land Senior Scientist (Next-generation sequencing) - Generative Biology Institute

✨Tip Number 1

Familiarise yourself with the specific next-generation sequencing technologies mentioned in the job description, such as Illumina and Oxford Nanopore. Being able to discuss your hands-on experience with these platforms during networking or interviews will demonstrate your suitability for the role.

✨Tip Number 2

Engage with current research and publications related to the Generative Biology Institute's focus areas. This will not only enhance your understanding but also provide you with relevant talking points when discussing how your expertise aligns with their mission.

✨Tip Number 3

Network with professionals in the field of genomics and synthetic biology, especially those who have experience in collaborative research environments. Attend relevant conferences or webinars to make connections that could lead to referrals or insights about the application process.

✨Tip Number 4

Stay updated on advancements in bioinformatics tools and programming languages like Python and R. Being able to showcase your coding skills and familiarity with bioinformatics packages can set you apart from other candidates and show your commitment to continuous learning.

We think you need these skills to ace Senior Scientist (Next-generation sequencing) - Generative Biology Institute

Next-generation sequencing expertise
Hands-on experience with Illumina, Oxford Nanopore, and PacBio technologies
Workflow development and troubleshooting
Bioinformatics analysis and interpretation
Familiarity with programming languages such as Python and R
Collaboration in multi-disciplinary research environments
Exceptional communication skills
Knowledge of laboratory automation systems
Experience with biological library screening techniques
Understanding of advanced sequencing methods like Hi-C and ChIP-Seq
Proficiency in bioinformatics tools such as Nextflow and GATK
Data management using LIMS and ELNs

Some tips for your application 🫡

Tailor Your CV: Make sure your CV highlights relevant experience in next-generation sequencing technologies and any hands-on work with platforms like Illumina or Nanopore. Emphasise your PhD or equivalent experience, and showcase your ability to develop and troubleshoot sequencing workflows.

Craft a Compelling Cover Letter: In your cover letter, express your passion for the role and the mission of the Generative Biology Institute. Discuss how your skills align with their goals, particularly in delivering high-quality sequencing data and collaborating with multidisciplinary teams.

Highlight Collaborative Experience: Since the role involves working closely with various research groups, be sure to mention any previous collaborative projects. Detail your communication skills and how you've successfully translated complex scientific concepts for non-specialists.

Showcase Continuous Learning: Mention any recent training or courses related to new sequencing technologies or bioinformatics tools. This demonstrates your commitment to staying updated in the field and your readiness to integrate improvements into existing workflows.

How to prepare for a job interview at Ellison Institute of Technology Oxford

✨Showcase Your Technical Expertise

Be prepared to discuss your hands-on experience with next-generation sequencing technologies like Illumina and Oxford Nanopore. Highlight specific projects where you developed or adapted sequencing workflows, as this will demonstrate your practical knowledge and problem-solving skills.

✨Emphasise Collaboration Skills

Since the role involves working closely with various research teams, share examples of past collaborations. Discuss how you effectively communicated complex scientific concepts to non-specialists, showcasing your ability to translate technical jargon into understandable terms.

✨Stay Updated on Industry Trends

Familiarise yourself with the latest advancements in sequencing technologies and methodologies. During the interview, mention any recent developments you've followed and how they could potentially enhance the work at the Generative Biology Institute.

✨Prepare for Problem-Solving Scenarios

Expect questions that assess your troubleshooting abilities. Be ready to discuss specific challenges you've faced in sequencing experiments and how you resolved them. This will illustrate your critical thinking and adaptability in a dynamic research environment.

Senior Scientist (Next-generation sequencing) - Generative Biology Institute
Ellison Institute of Technology Oxford

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