Senior Bioinformatician

About The Role

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges.

Key Responsibilities Of The Role

• Perform analysis and interpretation of large-scale single-cell and multi-omic datasets (e.g. scRNA-seq, spatial transcriptomics, CRISPR, scATAC-seq) to derive meaningful biological insight.
• Use molecular and cellular biology knowledge to design biologically informed analytical approaches, critically interpret results, and ensure that methodological decisions align with experimental design and research aims.
• Implement innovative and creative data analysis strategies beyond standard pipelines to address complex research challenges and explore new directions.
• Work collaboratively as an active intellectual partner within the Vento interdisciplinary team, participating in scientific discussions and collaborative problem-solving to ensure computational approaches align with experimental work.
• Feedback results to project leaders and colleagues when required to achieve deadlines.
• Organise and keep track of developed codes and generated data within the group.
• Prepare high-quality data reports to communicate results, including through publication and presentations at scientific meetings.
• Take a full part in the general duties of the team, and to pass on skills and knowledge to other team members and visitors. To take part in wider Sanger Institute activities as appropriate.

About You

You are a researcher with experience in computational biology and cell biology. You are motivated by the opportunity to advance our understanding of human immunology and contribute to meaningful scientific discoveries. You have experience analysing and interpreting transcriptomic and genomic data, and you are seeking a senior research role that integrates immune biology with cutting-edge genomic and computational approaches. You work with precision and enjoy solving complex problems, while remaining open to learning in areas where you have less experience. Collaboration is central to your work, and you value constructive dialogue, shared problem-solving, and meeting deadlines within a supportive team environment.

Essential Skills

• MSC or PhD in a relevant biological, computational or quantitative discipline (e.g. Bioinformatics, Computational Biology, Genetics, Biomedicine, Computer Science, Physics, etc); or equivalent working experience in Bioinformatics or a related discipline.
• Experience in a research environment with an established track record of productivity through publications, or writing reports in the industry.
• Experience in the fields of genomics and transcriptomics, data processing and high-throughput data analysis.
• Solid understanding of molecular and cellular biology, with the ability to formulate biological questions and interpret transcriptomic data within experimental context.
• Experience programming in high-level scripting languages (Preferably Python and/or R), and the Unix Shell.
• Enthusiastic, proactive attitude and desire to learn.
• Strong communication skills to allow efficient interactions with team members.
• Commitment, problem-solving skills and attention to detail.
• Ability to organise own workload and manage competing priorities.
• Ability to summarise complex information and present to a wide variety of audiences in a concise and logical manner.
• Demonstrates inclusivity and respect for all.

Other Information

Please upload your cover letter along with your current CV to apply.

Closing date:

10th February

Salary:

£44,905- 53,887

Relevant Publication Of The Groups

• CellPhoneDB v5: inferring cell-cell communication from single-cell multiomics data.
• Spatial multiomics map of trophoblast development in early pregnancy.
• Single-cell roadmap of human gonadal development.
• Robust temporal map of human in vitro myelopoiesis using single-cell genomics.
• Hybrid Working At Wellcome Sanger
• Equality, Diversity And Inclusion
• Our Benefits

Hybrid Working At Wellcome Sanger

We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.

Equality, Diversity And Inclusion

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

Our Benefits

We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.