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For Companies At a Glance
- Tasks: Lead innovative research in TCR cell therapy, designing and executing functional assays.
- Company: Join a cutting-edge biotech in Oxfordshire focused on next-gen immunotherapies for solid tumours.
- Benefits: Enjoy a competitive salary of £50,000-£60,000 plus benefits and opportunities for professional growth.
- Why this job: Be part of a mission-driven team making a real impact in oncology with advanced therapies.
- Qualifications: PhD in relevant fields and 3 years of experience in TCR-T or CAR-T therapies required.
- Other info: Mentorship opportunities available; collaborate with diverse teams in a fast-paced environment.
The predicted salary is between 42500 - 67500 £ per year.
Senior Scientist TCR Cell Therapy (Oncology)
Location: Oxfordshire
Department: R&D Oncology / Cell Therapy
Salary: £50,000£60,000 pa plus Benefits
About Us
Executive Recruitment have again been retained by this innovative biotech based in Oxfordshire specialising in engineered T-cell receptor (TCR-T) therapies targeting solid tumours. Their mission is to deliver next-generation immunotherapies with enhanced specificity and clinical impact. To that end we are looking to speak with Senior Scientists within this niche area of expertise. More about the role below.
Key Responsibilities
- Lead design and execution of in?vitro and ex?vivo functional assays to evaluate engineered TCR-T constructs (cytotoxicity, proliferation, cytokine release).
- Develop and optimise immunophenotyping methods using multi-colour flow cytometry, ELISA/ELISPOT, T-cell isolation, expansion, and killing assays.
- Conduct preclinical study designs, including lentiviral/retroviral transduction of T cells, gene editing (e.g., CRISPR/Cas9), and cell therapy process development.
- Interpret experimental data, drive go/no-go decision-making, and present findings internally and externally.
- Mentor junior scientists, maintain lab quality standards, and collaborate with cross-functional teams (bioinformatics, translational research, in?vivo).
- Stay updated on TCR-T and CAR-T advances, incorporating new technologies and publications into R&D strategy.
Technical Skills
- Fluency in multi-parameter flow cytometry (including immunophenotyping and high-content analysis)
- Robust experience with functional T-cell assays (cytotoxicity, proliferation, cytokine release, ELISPOT)
- Molecular biology expertise: gene editing (CRISPR), stable cell line generation, gene expression analysis
- Familiarity with pre-clinical in?vivo or translational assay systems (desirable)
Professional Skills
- Strong analytical capabilities with data interpretation and statistical presentation
- Excellent written/oral communication. Comfortable presenting to multidisciplinary audiences and publishing scientific outputs
- Proven ability to mentor and manage junior staff
- Collaborative mindset within cross-functional, fast-paced R&D teams
Education & Experience
- PhD in Immunology, Cell Biology, Molecular Biology, or related field (MSc industry experience may be considered)
- 3 years post-doctoral or industrial experience working with TCR-T or CAR-T cell therapies
- Experience with viral vectorbased transduction, T-cell isolation/expansion, gene editing, and primary human cell assays
If you have the skills, experience and desire to part of this industry leading company then please do not hesitate to apply.
Senior Scientist - TCR Cell Therapy (Oncology) employer: Executive Recruit
Contact Detail:
Executive Recruit Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Scientist - TCR Cell Therapy (Oncology)
✨Tip Number 1
Network with professionals in the field of TCR cell therapy and oncology. Attend relevant conferences, webinars, or workshops to meet potential colleagues and learn about the latest advancements. This can help you gain insights into the company culture and possibly get a referral.
✨Tip Number 2
Stay updated on the latest research and developments in TCR-T and CAR-T therapies. Familiarise yourself with recent publications and breakthroughs, as this knowledge will not only enhance your understanding but also demonstrate your passion and commitment during interviews.
✨Tip Number 3
Prepare to discuss your hands-on experience with relevant techniques such as flow cytometry, gene editing, and functional assays. Be ready to provide specific examples of how you've applied these skills in previous roles, as practical experience is highly valued in this position.
✨Tip Number 4
Showcase your mentoring and leadership abilities. Think of instances where you've guided junior scientists or led projects, as this role requires collaboration and management within cross-functional teams. Highlighting these experiences can set you apart from other candidates.
We think you need these skills to ace Senior Scientist - TCR Cell Therapy (Oncology)
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in TCR-T or CAR-T cell therapies. Emphasise your technical skills, such as flow cytometry and gene editing, and include any specific projects that demonstrate your expertise.
Craft a Compelling Cover Letter: Write a cover letter that connects your background to the role. Discuss your passion for oncology and immunotherapy, and mention how your experience aligns with the company's mission to deliver next-generation immunotherapies.
Highlight Leadership Experience: Since the role involves mentoring junior scientists, be sure to showcase any leadership or mentoring roles you've held. Provide examples of how you've guided teams or contributed to collaborative projects.
Showcase Communication Skills: Given the importance of presenting findings to multidisciplinary audiences, include examples of your written and oral communication skills. Mention any publications or presentations you've made in the field.
How to prepare for a job interview at Executive Recruit
✨Showcase Your Technical Expertise
Be prepared to discuss your experience with multi-parameter flow cytometry and functional T-cell assays in detail. Highlight specific projects where you successfully developed or optimised these methods, as this will demonstrate your hands-on skills and knowledge relevant to the role.
✨Prepare for Data Interpretation Questions
Since strong analytical capabilities are crucial for this position, expect questions that assess your ability to interpret experimental data. Practice explaining your thought process behind go/no-go decision-making based on data analysis from previous projects.
✨Emphasise Your Mentoring Experience
As mentoring junior scientists is part of the role, be ready to share examples of how you've guided or supported less experienced colleagues. Discuss your approach to fostering a collaborative environment and how you’ve contributed to their professional development.
✨Stay Updated on Industry Advances
Demonstrating your knowledge of recent advancements in TCR-T and CAR-T therapies can set you apart. Be prepared to discuss any new technologies or publications that have influenced your work, showing your commitment to staying at the forefront of the field.
