Discovery Safety Scientist

We are looking for a discovery toxicologist to provide significant support to our extensive portfolio of drug discovery programs. Working in close collaboration with relevant disciplines at Evotec and those of our partners, you will apply your deep understanding of discovery toxicology to rapidly advance projects from target identification to preclinical development. Working across a diverse range of indications and modalities, you will be responsible for the nonclinical safety strategy of multiple projects, including the design, interpretation, reporting and communication of discovery safety studies. This role reports to the VP Project Toxicology and Discovery Safety and may be based at any of our global offices with the potential for flexible working arrangements available.

Evotec is a global pharmaceutical business. Evotec covers all activities from target-to-clinic to meet the industry’s need for innovation and efficiency in drug discovery and development. The Company has established a unique position by assembling top-class scientific experts and integrating state-of-the-art technologies as well as substantial experience and expertise in key therapeutic areas including neuronal diseases, diabetes and complications of diabetes, pain and inflammation, oncology, infectious diseases, respiratory diseases and fibrosis.

Main Responsibilities will include:

• Responsible for the scientific oversight of discovery toxicology studies conducted across multiple projects at Evotec.
• Analyse, interpret and present toxicology data to project teams, updating risk assessments and applying knowledge and experience to impact project decisions.
• Develop and oversee target de-risking strategies for new projects based on the outcomes of target safety assessments.
• Provide timely safety/toxicology guidance to project teams at all stages of the drug development process.
• Provide project teams with an understanding of the predictivity of in silico and in vitro toxicology methods, their translatability in vivo and the associated clinical impact.
• Bridge the gap between discovery and development toxicology, allowing more consistency and streamlining of processes that affect project progression.
• Keep up to date with the latest NAMs and their potential to impact current paradigms at Evotec.

Knowledge and Experience:

• Significant and varied experience working in the field of toxicology, with a detailed working knowledge of at least one area of discovery toxicology.
• Sound knowledge of designing and delivering nonclinical safety development strategies for small molecules and biologics in the pharmaceutical industry.
• Experience in experimental design and data interpretation of early safety studies and their translatability relating to drug development.
• Working knowledge of GLP regulations, ICH, OECD, FDA, EMA and other regulatory guidelines, and their application to the design of appropriate nonclinical safety studies.
• Knowledge of early target safety assessments with a focus on target de-risking strategies using bespoke or globally accepted in vitro techniques.
• Strong organisational and communication skills.
• Ability to work under pressure, manage multiple projects and deliver to defined timelines.
• Familiarity with working within small and large molecule drug discovery programs as a nonclinical safety representative with a basic understanding of associated disciplines, e.g. biomarkers, DMPK, biology, medicinal chemistry.
• Knowledge of predictive in vivo toxicology studies routinely performed during early phases of drug development.
• Aware of in silico toxicology and how predictions can guide risk strategies for project teams.

Education and Qualifications:

• BSc or higher in a relevant scientific discipline such as toxicology, pharmacology, etc.
• DBAT/ERT/UKRT certification desirable.

Company Benefits:

• Company Pension Scheme on completion of your 3-month probationary period. Contributions start at 6% employee and employer, Evotec will match up to 7.5%.
• 25 days holiday plus bank holidays and additional length of service days awarded on the anniversary, up to a maximum of 30 days.
• Private health insurance with BUPA for the employees and their partner/family under the company scheme.
• Private dental cover, after 3 months service.
• Life assurance at four times your annual base salary.
• Wellbeing support 24/7 and counselling services.
• Permanent health insurance providing 75% of base salary after the qualifying period.
• Subsidised on premise restaurant.
• Eligibility to participate in the Company Bonus Scheme. This is a discretionary benefit.
• We have excellent training and support and continuing professional development opportunities.
• Cycle to work scheme.
• Discounted Gym Membership.
• Refer a friend scheme, team and annual events, recognition awards and many more!

Onsite Facilities also include: Onsite parking. Good public transport links with the shuttle bus service.