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- Tasks: Join a cutting-edge project studying RNA polymerase's response to DNA damage using advanced biophysical techniques.
- Company: Be part of the prestigious University of Oxford, renowned for its research and innovation.
- Benefits: Gain teaching experience, collaborate internationally, and develop interdisciplinary skills in a supportive environment.
- Why this job: This role offers a unique chance to impact scientific understanding while working in a dynamic, collaborative lab culture.
- Qualifications: Ph.D. (or near completion) in quantitative biochemistry or biophysics with strong experimental skills required.
- Other info: Fixed-term position for 3 years, with onboarding planned for fall 2025.
The predicted salary is between 28800 - 48000 £ per year.
We are looking to hire an outstanding experimentalist for an exciting project at the interface of biophysics and biochemistry that aims to understand the response of RNA polymerase to DNA damage-induced transcription stress. This is a fixed-term position for 3 years.
What are you going to do?
- Employ advanced biophysical instrumentation based on optical trapping or fluorescence microscopy to study RNA polymerase and its response to DNA damage-induced transcription stress;
- Develop an interdisciplinary skillset by acquiring practical knowledge of protein purification, ensemble biochemistry, and sample preparation to support your biophysical studies;
- Interact with biochemist and structural biology collaborators at Oxford and in the Netherlands (Erasmus MC and Netherlands Cancer Institute) in collaborative projects;
- Suggest ways to expand the interdisciplinary skillset as needed for the project's benefit;
- Employ simulations and data analysis routines to analyze your data;
- Publish your results with collaborators;
- Have the opportunity to gain teaching experience and improve leadership skills while guiding undergraduate and graduate students.
About the project Requirements
For this innovative, interdisciplinary project, we seek an excellent scientist with:
- A successfully completed Ph.D. degree (or close to completion) in quantitative biochemistry or biophysics;
- Practical experience and scientific maturity in these areas;
- Strong experimental and quantitative skills;
- An interest in working at the interface of biophysics, biochemistry, and structural biology (and developing relevant skills if not already present);
- An independent, well-organized, and reliable work style, with the ability and interest to work in a small team;
- Good interpersonal communication skills and a strong interest in the broader fields of replication and transcription, contributing to collaborative work and our interactive lab culture.
We welcome friendly and driven colleagues to enrich our team. We aim to onboard our new colleague in fall 2025.
Contact Detail:
TN United Kingdom Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Postdoctoral Research Assistant in single-molecule biophysics of DNA damage-induced transcripti[...]
✨Tip Number 1
Network with current and former researchers in the field of biophysics and biochemistry. Attend relevant conferences or seminars at institutions like the University of Oxford to make connections that could lead to valuable insights about the role and the team.
✨Tip Number 2
Familiarise yourself with the latest advancements in single-molecule biophysics and RNA polymerase research. Being well-versed in current literature will not only enhance your discussions during interviews but also demonstrate your genuine interest in the project.
✨Tip Number 3
Prepare to discuss your practical experience with advanced biophysical instrumentation, such as optical trapping or fluorescence microscopy. Be ready to share specific examples of how you've applied these techniques in your previous work.
✨Tip Number 4
Showcase your collaborative spirit by highlighting any past interdisciplinary projects you've been involved in. Emphasising your ability to work well with biochemists and structural biologists will align with the team's focus on collaboration.
We think you need these skills to ace Postdoctoral Research Assistant in single-molecule biophysics of DNA damage-induced transcripti[...]
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in biophysics and biochemistry. Emphasise any practical skills you have, such as optical trapping or fluorescence microscopy, and include details of your Ph.D. work that align with the job description.
Craft a Compelling Cover Letter: Write a cover letter that not only outlines your qualifications but also expresses your enthusiasm for the project. Mention specific aspects of the research that excite you and how your background makes you a great fit for the role.
Highlight Interdisciplinary Skills: Since the position involves collaboration across different fields, be sure to showcase any interdisciplinary skills you possess. Discuss experiences where you've worked with biochemists or structural biologists, and how you can contribute to the team.
Proofread Your Application: Before submitting, carefully proofread your application materials. Check for spelling and grammatical errors, and ensure that all information is clear and concise. A polished application reflects your attention to detail and professionalism.
How to prepare for a job interview at TN United Kingdom
✨Showcase Your Experimental Skills
Be prepared to discuss your hands-on experience with biophysical instrumentation, such as optical trapping or fluorescence microscopy. Highlight specific projects where you successfully applied these techniques, as this will demonstrate your practical knowledge and scientific maturity.
✨Emphasise Interdisciplinary Collaboration
Since the role involves working with biochemists and structural biologists, be ready to talk about any past collaborative projects. Share examples of how you effectively communicated and contributed to a team, showcasing your interpersonal skills and ability to work in an interdisciplinary environment.
✨Demonstrate Your Problem-Solving Abilities
Prepare to discuss challenges you've faced in your research and how you overcame them. This could include issues related to data analysis or experimental design. Showing your analytical thinking and resilience will impress interviewers looking for a reliable and independent candidate.
✨Express Your Passion for Teaching and Leadership
If you have any teaching experience or have mentored students, make sure to mention it. Discuss your interest in guiding undergraduates and graduates, as this aligns with the opportunity to gain teaching experience in the role. It shows that you're not only focused on your research but also on contributing to the academic community.
