Senior Manager, Corporate Applications

This job is with Autolus Therapeutics, an inclusive employer and a member of myGwork – the largest global platform for the LGBTQ+ business community. Please do not contact the recruiter directly.

Job Title

 Senior Manager, Corporate Applications

Reports to

 Senior Director, Application Management

Department

 IT Application Management

Hours

 Full-time

Location

 UK (London)

About Autolus

Autolus is a biopharmaceutical company, advancing innovative therapies at both clinical and commercial stages of development, focused on next-generation, programmed T cell therapies for the treatment of cancer. Using a broad suite of proprietary and modular T cell programming technologies, the company is engineering precisely targeted, controlled, and highly active T cell therapies designed to better recognize cancer cells, break down their defence mechanisms, and eliminate these cells. Autolus has a pipeline of product candidates in development for the treatment of haematological malignancies, solid tumours, and autoimmune diseases.

Why Autolus

Our team is passionate in the pursuit of excellence and in pushing the boundaries of cancer therapy and autoimmune diseases to deliver life-changing treatments to patients. Whilst working at Autolus you will enjoy a flexible, diverse, and dynamic working environment which actively promotes creativity, leadership and teamwork. In addition to this Autolus is proud to offer a competitive salary, performance related bonus as well as private medical insurance, life assurance, and pension.

Our Promise

Autolus is developing complex, breakthrough therapies for a globally diverse market and equally recognises that diversity amongst our people is critical to our mission. As we draw on our differences, what we’ve experienced, and how we work, we celebrate diversity and are committed to creating an inclusive environment for all employees.

Role Summary

We are looking for a skilled Applications Manager, Corporate Systems to lead and manage our suite of internal enterprise applications supporting Finance, Supply Chain, HR, Compliance, and Legal teams. This includes systems such as Microsoft Dynamics 365 (ERP/MRP/Supply Chain), Workday (HRIS), ComplianceWire, Contract Lifecycle Management (CLM) tools, and integration platforms like MuleSoft. The successful candidate will ensure the health, performance, and continual evolution of these systems through metrics-driven governance and clear roadmapping, enabling business growth with strong controls and data integrity.

Key Responsibilities

• Serve as the IT system owner and strategic lead for internal corporate systems: D365 (ERP, MRP, Supply Chain), Workday, Compliance Wire, CLM, MuleSoft integrations, and related platforms.
• Define and manage the application roadmap in collaboration with IT business partners and system owners across Finance, Supply Chain, HR, Compliance, and Legal.
• Partner with PMO to execute successful technical implementations, upgrades, and rollouts.
• Lead a team of business analysts and solutions architects, coaching them through sprints, backlog management, and on-time delivery.
• Identify and drive process efficiencies, reduce technical debt, and champion best practices.
• Manage vendor and MSP relationships, ensuring SLAs are met and budgets are maintained.
• Own release planning, testing, change management, and post-rollout support.
• Establish and monitor KPIs around system uptime, performance, user adoption, utilization rates, and data quality.
• Oversee user access, roles, and permissions with strong data governance and security protocols.
• Collaborate with Legal, Compliance, Security, and QA to maintain regulatory alignment (e.g., GxP, SOX, GDPR).
• Mentor analysts or administrators and engage vendor expertise as needed.
• Support enterprise-wide initiatives such as system consolidation, international expansion, and operating model evolution.

Experience

• Deep experience managing enterprise systems—ERP, HRIS, compliance systems, and integration platforms—preferably in biotech, pharma, or regulated environments.
• Proven track record owning full system lifecycles, including strategy, roadmapping, implementation, support, and upgrades.
• Hands-on expertise with Microsoft Dynamics 365, Workday, MuleSoft, ComplianceWire, and CLM platforms.
• Strong capabilities in integration architecture, API/data flow design, and performance monitoring.
• Demonstrated ability to manage application metrics and dashboards for system health and business adoption.
• Experience leading internal IT teams or vendors, with proven stakeholder management across functions.
• Knowledge of regulatory standards and frameworks (SOX, GxP, GDPR).
• Effective communicator with excellent leadership and collaboration skills.
• Bonus: experience within the CAR-T or broader cell therapy landscape.
• Bachelor’s degree in Computer Science, Information Systems, Life Sciences, or related field (Master’s preferred).

Autolus Core Competencies

Focus on Results: Works to meet business goals set by management and leaders

Builds Trust and Relationships: Ensures trust with internal and external partners by delivering on commitments

Resilience: Has the capacity to recover quickly from difficulties; toughness

Communicates and Collaborates: Builds partnerships and works collaboratively with others to meet objectives

Autolus is committed to the protection of the personal information that we collect & process and we are fully compliant with General Data Protection Regulations (GDPR)

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