Biophysics Scientist / Senior Scientist

Sygnature Discovery is a world-leading integrated drug discovery Contract Research Organisation based in the UK and Canada with its headquarters in Nottingham and additional facilities in Alderley Park, Macclesfield, Glasgow, Montreal and Quebec City. Its staff of over 1,000, which includes 900 scientists, partners with global pharma, biotech and NFP organisations. Since 2004, Sygnature Discovery has delivered over 40 novel pre-clinical and 22 clinical compounds, with its scientists named on over 170 patents. Therapeutic areas of expertise include oncology, inflammation and immunology, neuroscience, metabolic diseases, infectious diseases, fibrotic diseases and more.

Biophysicists at Sygnature Discovery play essential roles in supporting and leading integrated client projects as well as developing and delivering customised biophysical assays to support and drive preclinical drug discovery campaigns. Through the generation of high-quality data, such as affinity and kinetic data to inform structure-activity relationships (SAR) and mechanism of action (MoA) investigations for complex systems, biophysics forms a key component of many single- and multi-discipline projects. Due to continued growth, we are expanding our talented Biophysics team at our Nottingham site. This is a full-time, onsite position.

Role Responsibilities:

• Utilise knowledge and experience of biophysical technologies on active drug discovery projects.
• Develop a detailed understanding of biophysical approaches and share knowledge of multiple techniques with the wider biophysics team.
• Present and share data and expertise to our global, multi-disciplinary biophysics and protein science groups.
• Be responsible for the maintenance of biophysical instrumentation.
• Provide support for other members of the team, such as junior team members or new instrument users, including instrument specific training where required.

Candidate Requirements:

• PhD or relevant experience in Pharmacology, Biochemistry or a related Biology-specific discipline.
• Hands-on expertise with SPR, MST, and DSF/FTSA is ideal.
• Experience with BLI, ITC, and NMR is desirable.
• A strong scientific track record with experience built within a drug discovery environment is highly desirable.
• A working knowledge of current trends in drug discovery.
• Ability to develop novel assays from first principles and interpret complex biological datasets.
• Aptitude for proactive troubleshooting and adoption of industry-leading practices for generation and analysis of robust scientific data.
• Ability to work independently and collaboratively within a fast-paced environment.
• Experience in project leadership or line management is desirable but not essential.
• Excellent written and verbal communication skills and an ability to present complex scientific ideas and datasets to key stakeholders.

Benefits:

• 25 days annual leave (rising with service) plus bank holidays, and buy/sell scheme.
• Private Medical Insurance.
• Life Insurance.
• Employee Assistance Programme and mental health first aiders.
• Enhanced Family Friendly Policies.
• Sygnature Group Pension Scheme.
• 1 paid volunteer day per year.
• A host of flexible benefits to support your wellbeing and lifestyle.

At Sygnature Discovery, we embody excellence in everything we do. From pioneering research to ground-breaking discoveries, we set the standard for scientific innovation. But it’s collaboration that truly defines us. Across continents and disciplines, we unite to solve complex challenges, driven by a shared passion for improving lives worldwide. We understand the importance of creating a work environment that empowers you to thrive. That’s why we have fostered a culture of collaboration and support, providing pathways for both professional and personal development. This includes a diverse range of bespoke training and development designed to accelerate both your personal and career growth. We are committed to fostering diversity and inclusion throughout our organisation. We encourage applications from individuals of all backgrounds, ethnicity, gender identity, sexual orientation, disability, neurodiversity, age, family or parental status, beliefs, nationalities and religions. We strive to cultivate an inclusive environment where all our colleagues feel empowered to bring their true selves to work.

If you’re interested in joining a company that places people at the heart of its business, please submit your application as soon as possible as we will be interviewing on an ongoing basis. If you have any questions or need further information, please contact the Talent Acquisition team.