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- Tasks: Lead and support downstream process development for innovative gene therapies.
- Company: Join a dynamic team focused on advancing AAV gene therapies from lab to market.
- Benefits: Enjoy a permanent role with opportunities for mentorship and collaboration.
- Why this job: Be at the forefront of gene therapy innovation and make a real impact in healthcare.
- Qualifications: PhD/EngD with 2+ years or MSc/BSc with 4+ years in downstream process development required.
- Other info: Ideal for those passionate about bioprocess improvement and scientific excellence.
The predicted salary is between 48000 - 72000 £ per year.
Are you ready to play a key role in advancing novel AAV gene therapies from development to commercialisation? We’re seeking a Downstream Process Development Scientist to join a collaborative and dynamic Manufacturing Sciences and Technology (MSAT) team. You’ll help shape the future of gene therapy by driving innovation in downstream and drug product unit operations—from early-stage development through to GMP tech transfer.
About the Role
- Lead or support the development of downstream processes (chromatography, filtration, TFF, formulation, fill/finish) for novel AAV products.
- Transfer processes from lab-scale to GMP facilities.
- Execute and document development studies and protocols.
- Contribute to clinical and commercial manufacturing campaigns.
- Mentor junior team members and contribute to the knowledge base within MSAT.
- Drive technical excellence and innovation, leveraging high-throughput tools, statistical and mechanistic modelling, and DoE principles.
- Collaborate cross-functionally with manufacturing, quality, and analytical teams.
Background and Qualifications
- PhD/EngD with 2+ years’ industry experience OR MSc/BSc with 4+ years’ experience in downstream process development.
Key Skills and Experience
- Experience with AAV purification, TFF, and chromatography (ion exchange, affinity, etc.).
- Understanding of GMP, QbD, and scale-up principles.
- Familiarity with statistical tools (DoE, ANOVA, t-tests, multivariate analysis).
- Analytical assay experience (qPCR, ELISA, HPLC, UV-spectrometry).
- Experience drafting SOPs, work instructions, and supporting regulatory documentation.
- Knowledge of mechanistic modelling, programming, or automated data handling is a bonus.
What We’re Looking For:
- A sharp analytical mindset and strong problem-solving skills.
- Collaborative spirit with the initiative to take ownership of work.
- A passion for improving bioprocesses through innovation and scientific rigour.
Senior Scientist employer: JR United Kingdom
Contact Detail:
JR United Kingdom Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Scientist
✨Tip Number 1
Make sure to highlight your experience with AAV purification and downstream process development in your conversations. This is a key area for the role, and demonstrating your expertise can set you apart from other candidates.
✨Tip Number 2
Network with professionals in the biopharmaceutical industry, especially those involved in gene therapy. Attend relevant conferences or webinars to connect with potential colleagues and learn more about current trends and challenges in downstream processing.
✨Tip Number 3
Prepare to discuss specific examples of how you've driven innovation in previous roles. Be ready to share instances where you've applied statistical tools or mechanistic modelling to improve processes, as this aligns well with what we're looking for.
✨Tip Number 4
Showcase your collaborative spirit by discussing past experiences where you've worked cross-functionally. Emphasising your ability to work with manufacturing, quality, and analytical teams will demonstrate that you're a great fit for our dynamic environment.
We think you need these skills to ace Senior Scientist
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in downstream process development, particularly with AAV purification and chromatography. Use specific examples to demonstrate your skills and achievements.
Craft a Compelling Cover Letter: Write a cover letter that showcases your passion for gene therapy and innovation in bioprocesses. Mention how your background aligns with the role and express your enthusiasm for contributing to the MSAT team.
Highlight Key Skills: In your application, emphasise your experience with GMP, QbD, and statistical tools. Be sure to mention any familiarity with analytical assays and mechanistic modelling, as these are key aspects of the role.
Proofread Your Application: Before submitting, carefully proofread your CV and cover letter for any errors or typos. A polished application reflects your attention to detail and professionalism, which is crucial for this position.
How to prepare for a job interview at JR United Kingdom
✨Showcase Your Technical Expertise
Be prepared to discuss your experience with AAV purification, TFF, and chromatography in detail. Highlight specific projects where you successfully developed downstream processes and how you applied statistical tools like DoE or ANOVA.
✨Demonstrate Collaborative Skills
Since the role involves cross-functional collaboration, be ready to share examples of how you've worked effectively with manufacturing, quality, and analytical teams. Emphasise your ability to communicate complex ideas clearly and work towards common goals.
✨Prepare for Problem-Solving Scenarios
Expect questions that assess your analytical mindset and problem-solving skills. Prepare to discuss challenges you've faced in previous roles and how you approached them, particularly in relation to bioprocess improvements and innovation.
✨Express Your Passion for Innovation
Convey your enthusiasm for advancing gene therapies and improving bioprocesses. Share any personal projects or research that demonstrate your commitment to scientific rigour and innovation in the field.
