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- Tasks: Lead PK/PD modelling strategies for drug development and collaborate with cross-functional teams.
- Company: Join a science-driven organisation focused on transformative therapies and innovative solutions.
- Benefits: Enjoy competitive salary, comprehensive benefits, and flexible work arrangements.
- Why this job: Make a real impact in drug development while growing your expertise in a collaborative environment.
- Qualifications: PhD or relevant degree with 5-8 years of PK/PD modelling experience required.
- Other info: Opportunity to mentor junior scientists and contribute to scientific publications.
The predicted salary is between 43200 - 72000 £ per year.
We are seeking an experienced and driven Senior PK/PD Modeller to join our Clinical Pharmacology team. In this role, you will be responsible for the design, development, and implementation of pharmacokinetic/pharmacodynamic (PK/PD) modeling strategies to support drug development across all phases. You will collaborate cross-functionally with pharmacometrics, clinical, regulatory, and nonclinical teams to provide quantitative insight into drug behavior and inform key decision-making.
Key Responsibilities:
- Lead the development and execution of PK/PD modeling and simulation strategies for preclinical and clinical programs.
- Perform population pharmacokinetics (PopPK), exposure-response (E-R), and physiologically-based pharmacokinetic (PBPK) modeling.
- Translate complex quantitative data into actionable insights for dose selection, trial design, and regulatory interactions.
- Author or contribute to clinical study protocols, pharmacometric analysis plans, and regulatory submissions (IND, NDA, BLA, MAA, etc.).
- Serve as subject matter expert in modeling approaches and mentor junior scientists in PK/PD methodologies.
- Collaborate with biostatistics, clinical pharmacology, regulatory affairs, and other key stakeholders to integrate modeling insights into overall development strategy.
- Maintain awareness of new scientific and regulatory developments in pharmacometrics and contribute to external publications and presentations when appropriate.
Qualifications:
- PhD in Pharmaceutical Sciences, Pharmacology, Applied Mathematics, Biomedical Engineering, or related field; or PharmD/MSc with significant modeling experience.
- Minimum of 5–8 years of hands-on experience in PK/PD modeling, preferably within the pharmaceutical or biotechnology industry.
- Proficiency in NONMEM, Monolix, R, Phoenix WinNonlin, MATLAB, or other relevant software tools.
- Strong understanding of regulatory guidance and expectations related to modeling and simulation (e.g., FDA, EMA).
- Demonstrated ability to interpret and communicate complex data effectively to both technical and non-technical stakeholders.
- Track record of contributions to regulatory filings and/or scientific publications.
- Strong analytical, organizational, and project management skills.
Preferred Skills:
- Experience in mechanistic modeling or QSP (Quantitative Systems Pharmacology).
- Familiarity with PBPK modeling platforms (e.g., Simcyp, GastroPlus).
- Experience in oncology, CNS, immunology, or other specific therapeutic areas is a plus.
- Leadership in cross-functional project teams.
Why Join Us?
You’ll be part of a collaborative and innovative environment where your expertise will directly impact the development of transformative therapies. We offer a competitive salary, comprehensive benefits, flexible work arrangements, and the opportunity to grow professionally in a science-driven organization.
Senior PKPD Modeller employer: Barrington James
Contact Detail:
Barrington James Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior PKPD Modeller
✨Tip Number 1
Network with professionals in the pharmacometrics and clinical pharmacology fields. Attend industry conferences or webinars to meet potential colleagues and learn about the latest trends in PK/PD modelling.
✨Tip Number 2
Familiarise yourself with the specific software tools mentioned in the job description, such as NONMEM and Monolix. Consider taking online courses or tutorials to enhance your proficiency and demonstrate your commitment to mastering these tools.
✨Tip Number 3
Stay updated on regulatory guidance related to PK/PD modelling by following relevant agencies like the FDA and EMA. This knowledge will not only help you in interviews but also show that you are proactive and informed about industry standards.
✨Tip Number 4
Prepare to discuss your previous experiences with cross-functional collaboration. Be ready to share specific examples of how you've worked with teams in biostatistics, clinical pharmacology, or regulatory affairs to integrate modelling insights into drug development strategies.
We think you need these skills to ace Senior PKPD Modeller
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your relevant experience in PK/PD modelling. Emphasise your hands-on experience with software tools like NONMEM, Monolix, and R, as well as any contributions to regulatory filings or scientific publications.
Craft a Strong Cover Letter: In your cover letter, express your passion for pharmacometrics and drug development. Mention specific projects where you led PK/PD modelling efforts and how they contributed to successful outcomes. Show how your skills align with the company's goals.
Highlight Collaborative Experience: Since the role involves cross-functional collaboration, be sure to include examples of how you've worked with teams from different disciplines. This could include interactions with biostatistics, clinical pharmacology, or regulatory affairs.
Showcase Continuous Learning: Mention any recent training, workshops, or conferences you've attended related to pharmacometrics or regulatory guidance. This demonstrates your commitment to staying updated on industry developments and enhances your application.
How to prepare for a job interview at Barrington James
✨Showcase Your Technical Skills
Be prepared to discuss your proficiency in relevant software tools like NONMEM, Monolix, and R. Highlight specific projects where you've successfully applied these skills in PK/PD modelling.
✨Demonstrate Cross-Functional Collaboration
Since the role involves working with various teams, share examples of how you've collaborated with pharmacometrics, clinical, and regulatory teams in the past. This will show your ability to integrate insights into a broader development strategy.
✨Prepare for Regulatory Discussions
Familiarise yourself with current regulatory guidance related to modelling and simulation. Be ready to discuss how your work has contributed to regulatory filings or scientific publications, as this is crucial for the role.
✨Communicate Complex Data Clearly
Practice explaining complex quantitative data in simple terms. You may encounter both technical and non-technical stakeholders, so demonstrating your ability to communicate effectively is key.
