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- Tasks: Lead PK/PD modelling strategies for drug development and collaborate with cross-functional teams.
- Company: Join a science-driven organisation focused on transformative therapies and innovative solutions.
- Benefits: Enjoy competitive salary, comprehensive benefits, and flexible work arrangements.
- Why this job: Make a real impact in drug development while growing your expertise in a collaborative environment.
- Qualifications: PhD or relevant degree with 5-8 years of PK/PD modelling experience required.
- Other info: Opportunity to mentor junior scientists and contribute to scientific publications.
The predicted salary is between 48000 - 72000 £ per year.
We are seeking an experienced and driven Senior PK/PD Modeller to join our Clinical Pharmacology team. In this role, you will be responsible for the design, development, and implementation of pharmacokinetic/pharmacodynamic (PK/PD) modeling strategies to support drug development across all phases. You will collaborate cross-functionally with pharmacometrics, clinical, regulatory, and nonclinical teams to provide quantitative insight into drug behavior and inform key decision-making.
Key Responsibilities:
- Lead the development and execution of PK/PD modeling and simulation strategies for preclinical and clinical programs.
- Perform population pharmacokinetics (PopPK), exposure-response (E-R), and physiologically-based pharmacokinetic (PBPK) modeling.
- Translate complex quantitative data into actionable insights for dose selection, trial design, and regulatory interactions.
- Author or contribute to clinical study protocols, pharmacometric analysis plans, and regulatory submissions (IND, NDA, BLA, MAA, etc.).
- Serve as subject matter expert in modeling approaches and mentor junior scientists in PK/PD methodologies.
- Collaborate with biostatistics, clinical pharmacology, regulatory affairs, and other key stakeholders to integrate modeling insights into overall development strategy.
- Maintain awareness of new scientific and regulatory developments in pharmacometrics and contribute to external publications and presentations when appropriate.
Qualifications:
- PhD in Pharmaceutical Sciences, Pharmacology, Applied Mathematics, Biomedical Engineering, or related field; or PharmD/MSc with significant modeling experience.
- Minimum of 5–8 years of hands-on experience in PK/PD modeling, preferably within the pharmaceutical or biotechnology industry.
- Proficiency in NONMEM, Monolix, R, Phoenix WinNonlin, MATLAB, or other relevant software tools.
- Strong understanding of regulatory guidance and expectations related to modeling and simulation (e.g., FDA, EMA).
- Demonstrated ability to interpret and communicate complex data effectively to both technical and non-technical stakeholders.
- Track record of contributions to regulatory filings and/or scientific publications.
- Strong analytical, organizational, and project management skills.
Preferred Skills:
- Experience in mechanistic modeling or QSP (Quantitative Systems Pharmacology).
- Familiarity with PBPK modeling platforms (e.g., Simcyp, GastroPlus).
- Experience in oncology, CNS, immunology, or other specific therapeutic areas is a plus.
- Leadership in cross-functional project teams.
Why Join Us?
You’ll be part of a collaborative and innovative environment where your expertise will directly impact the development of transformative therapies. We offer a competitive salary, comprehensive benefits, flexible work arrangements, and the opportunity to grow professionally in a science-driven organization.
Senior PKPD Modeller employer: Barrington James
Contact Detail:
Barrington James Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior PKPD Modeller
✨Tip Number 1
Network with professionals in the pharmacometrics and clinical pharmacology fields. Attend relevant conferences or webinars to meet potential colleagues and learn about the latest trends in PK/PD modelling.
✨Tip Number 2
Familiarise yourself with the specific software tools mentioned in the job description, such as NONMEM and Monolix. Consider taking online courses or tutorials to enhance your proficiency and demonstrate your commitment to mastering these tools.
✨Tip Number 3
Stay updated on regulatory guidance related to pharmacokinetics and pharmacodynamics. Understanding the expectations of agencies like the FDA and EMA will help you articulate how your skills align with the company's needs during interviews.
✨Tip Number 4
Prepare to discuss your past experiences in leading cross-functional teams and mentoring junior scientists. Highlight specific examples where your contributions made a significant impact on project outcomes, as this aligns well with the responsibilities of the role.
We think you need these skills to ace Senior PKPD Modeller
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in PK/PD modelling and showcases your proficiency with software tools like NONMEM, Monolix, and R. Emphasise any leadership roles or cross-functional collaborations you've been involved in.
Craft a Strong Cover Letter: In your cover letter, express your passion for drug development and how your background aligns with the responsibilities of the Senior PKPD Modeller role. Mention specific projects where you successfully applied your modelling expertise.
Highlight Relevant Qualifications: Clearly state your educational qualifications, especially your PhD or MSc, and any significant modelling experience. Include details about your understanding of regulatory guidance related to modelling and simulation.
Showcase Communication Skills: Demonstrate your ability to communicate complex data effectively. Provide examples of how you've translated quantitative insights into actionable strategies for both technical and non-technical stakeholders in your application.
How to prepare for a job interview at Barrington James
✨Showcase Your Technical Skills
Be prepared to discuss your experience with PK/PD modelling tools like NONMEM, Monolix, and R. Highlight specific projects where you successfully applied these skills, as this will demonstrate your hands-on expertise.
✨Understand Regulatory Expectations
Familiarise yourself with the regulatory guidance related to modelling and simulation from agencies like the FDA and EMA. Being able to articulate how your work aligns with these expectations can set you apart.
✨Communicate Complex Data Clearly
Practice explaining complex quantitative data in simple terms. You may encounter both technical and non-technical stakeholders during the interview, so showcasing your ability to bridge that gap is crucial.
✨Demonstrate Leadership and Collaboration
Prepare examples of how you've led cross-functional teams or mentored junior scientists. This role requires collaboration across various departments, so showing your leadership skills will be beneficial.
