Process Development Chemist

Quotient Sciences is a drug development and manufacturing accelerator providing integrated programs and tailored services across the entire development pathway. We help biotech and pharma customers save precious time and money in getting drugs to patients.

We employ more than 1,100 talented individuals globally, located at state-of-the-art development, manufacturing and clinical facilities in the UK and USA. Science, Agility and Culture are the core components that define Quotient Sciences.

An opportunity has arisen for a Process Development Chemist to join our Drug Substance team. The position will report to a Process Chemistry Team Leader and will perform and manage chemical syntheses in accordance with regulatory and company procedures.

Main tasks and responsibilities:

• Design and execute synthetic routes to target molecules.
• Develop safe, compliant, scalable, and economically viable processes for downstream manufacture of API and intermediates within agreed timeframes.
• Apply chemical knowledge to ensure that target molecules meet the expected target product profile.
• Provide written, oral, and presentation updates on project progress to clients and other stakeholders.
• Guide and counsel other department members through synthetic problems they might encounter and contribute to the resolution of same.
• Ensure that self and others using laboratories handle and dispose of materials in accordance with agreed company practices and procedures.
• Plan and perform syntheses/purifications of various chemical entities within agreed timeframes.
• Maintain Laboratory Notebook, ensuring that this is countersigned, and contribute to countersigning others' books as assigned.
• Ensure that work is conducted in compliance with relevant regulatory requirements, internal policies/procedures and client requirements where appropriate.
• Assist in the selection of equipment and, with Facilities, prepare CAPEX justifications for purchase of equipment as required.
• Maintain laboratory systems that have been implemented as a result of GMP action programmes.
• Contribute to laboratory operations, equipment acquisition and maintenance, contracts, housekeeping, stock control, disposals and liaise with other departments dealing with such matters.
• Ensure, where required, that laboratory work and associated documentation complies with GMP or other regulatory requirements, internal policies and procedures and client requirements.
• Participate in and produce process risk assessments for processes to be scaled up on site.
• Work with due regard to health and safety of self and others. Work flexibly across the site to meet business needs.

The Candidate

The successful candidate will have a good knowledge and experience of synthetic organic chemistry covering process optimisation and cost-effective scale up, awareness of the current regulatory environment, impurity control and a good understanding of the factors controlling API physical form.

Other skills and experience required:

• A graduate degree in Chemistry, ideally with a PhD in Synthetic Organic Chemistry or a closely related discipline or post-graduate industrial experience.

Application Requirements

When applying for a position with Quotient Sciences, to be able to work in our organisation you must be aged 18 years or over and not have been debarred by the FDA. If you indicate you are under the age of 18 or have been debarred, then your application will be automatically declined.

Our Commitment to Diversity, Equity and Inclusion

Quotient Sciences are advocates for positive change and conscious inclusion. We strive to create a diverse Quotient workforce and develop a workplace culture that provides a sense of acceptance for every person within our organisation.

As a global employer, we recognise the value in having an organisation that is a true reflection and representation of our society today. Specifically, we will not discriminate on the basis of race, colour, creed, religion, gender, gender identity, pregnancy, marital status, partnership status, domestic violence victim status, sexual orientation, age, national origin, alienage or citizenship status, veteran or military status, disability, medical condition, genetic information, caregiver status, unemployment status or any other characteristic prohibited by federal, state and/or local laws.

This applies to all aspects of employment, including hiring, promotion, demotion, compensation, training, working conditions, transfer, job assignments, benefits, layoff, and termination.