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- Tasks: Join us to design and analyse experiments for vaccine development against a major livestock parasite.
- Company: The Pirbright Institute leads cutting-edge research on viral diseases affecting livestock, enhancing global health.
- Benefits: Enjoy 25 days annual leave, a generous pension scheme, and subsidised gym membership.
- Why this job: Make a real impact in vaccine research while collaborating with a vibrant scientific community.
- Qualifications: PhD in immunology or related field; experience in antibody discovery and strong teamwork skills required.
- Other info: This is a 24-month fixed-term contract based in Woking, GU24.
The predicted salary is between 33500 - 38000 £ per year.
The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our major strength in understanding the immune systems of livestock provides a platform to control current diseases and respond to emerging threats.
We are seeking a highly motivated Postdoctoral Scientist to join a collaborative project between The Pirbright Institute and The Moredun Research Institute, funded by the Bill & Melinda Gates Foundation. The project aims to develop novel vaccines against Haemonchus contortus, a major parasitic threat to small ruminants worldwide, which has a significant economic impact on global livestock industries. The primary objective is to generate a library of functionally-relevant sheep monoclonal antibodies (mAbs) against H. contortus to inform vaccine development and selection.
The Postdoctoral Scientist will work within the Immunogenetics and Immunological Toolbox Groups, applying cutting-edge antibody discovery techniques, including single-cell antibody sequencing, spectral flow cytometry, and high-throughput antibody expression systems. The role offers an exciting opportunity to contribute directly to vaccine research by characterising H. contortus-specific mAbs and advancing our understanding of host-parasite interactions.
Main duties and responsibilities:
- Designing, Performing, and Analysing Experiments (80%)
- Design and execute experiments to isolate H. contortus (H-gal-GP complex antigen) specific mAbs from sheep using single B cell discovery technologies. (30%)
- Recombinant expression and purification of sheep monoclonal antibodies (IgGs isotypes) using a mammalian expression system. (20%)
- Develop assays to characterise antibody binding and function. (20%)
- Analyse experimental data using appropriate statistical and analytical tools. (10%)
- Provide support to other members of the team as required, including assisting with their experiments and projects. (10%)
- Train and supervise colleagues across other groups on experimental techniques and procedures offered by Immunological Toolbox. (5%)
- Participate in lab management including equipment maintenance, inventory management, and adherence to safety protocols. (5%)
- Communicate research progress and findings through regular team meetings and reports.
- Prepare high-quality manuscripts for publication in peer-reviewed journals.
- Present research findings at national and international scientific conferences.
- Ensure compliance with health, safety, and biosecurity regulations to maintain a safe and effective working environment.
- Engage in interdisciplinary collaborations within The Pirbright Institute and with external partners.
- Serve on relevant committees and participate in outreach and public engagement activities.
- Support the broader scientific mission of the Institute by contributing to strategic research initiatives and funding proposals.
Due to the nature of the work we do, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances.
Essential/Desirable requirements
- Essential
- PhD (or equivalent experience) in immunology, molecular biology, or a related bioscience field.
- A broad understanding of immunology and antigen receptors.
- Proficiency in designing assays with a keen attention to detail, ensuring the inclusion of appropriate controls to validate experimental results.
- Strong background in antibody biology, B cell immunology, and antigen recognition.
- Hands-on experience with antibody discovery techniques, including flow cytometry and molecular cloning.
- Strong communication and teamwork skills, with a record of productive scientific collaboration.
- Experience in recombinant antibody production and high-throughput expression systems.
- Knowledge of next-generation sequencing (NGS) techniques for antibody discovery.
- Expertise in functional assays, including ELISA, ELISpot, ADCC, and ADCP.
- A strong publication record in immunology, molecular biology, or related disciplines.
What we offer
- Generous Group Personal Pension Scheme and life cover (subject to age and earnings)
- 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days
- Buy and sell annual leave
- Option to carry over up to two weeks annual leave
- Pirbright gym with subsidised membership
- Pirbright social club
- Pirbright Lifestyle Hub (employee discount site)
- Cycle to work
- Subsidised employee restaurant
- Childcare allowance
- Free onsite parking
Due to the high volume of applications we receive, if you have not heard from us within one month from closing date of the vacancy, then please contact us on jobs@pirbright.ac.uk for an update.
Postdoctoral Research Scientist employer: The Pirbright Institute
Contact Detail:
The Pirbright Institute Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Postdoctoral Research Scientist
✨Tip Number 1
Network with professionals in the field of immunology and antibody research. Attend relevant conferences or seminars where you can meet researchers from The Pirbright Institute and discuss your interests and experiences.
✨Tip Number 2
Familiarise yourself with the latest advancements in antibody discovery techniques, particularly single-cell antibody sequencing and flow cytometry. Being well-versed in these methods will demonstrate your commitment and readiness for the role.
✨Tip Number 3
Engage with the research outputs of The Pirbright Institute by reading their publications. This will not only enhance your understanding of their work but also provide you with talking points during interviews.
✨Tip Number 4
Consider reaching out to current or former employees of The Pirbright Institute on professional networking platforms. They can offer insights into the work culture and expectations, which can be invaluable during your application process.
We think you need these skills to ace Postdoctoral Research Scientist
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in immunology, molecular biology, and antibody discovery techniques. Use specific examples from your past work that align with the responsibilities outlined in the job description.
Craft a Strong Cover Letter: Write a cover letter that clearly explains your motivation for applying to The Pirbright Institute. Discuss how your skills and experiences make you a suitable candidate for the Postdoctoral Research Scientist role, particularly in relation to vaccine development and research communication.
Highlight Collaborative Experience: Since the role involves collaboration, emphasise any previous teamwork or interdisciplinary projects you've been part of. Mention how you contributed to these projects and what you learned from them.
Proofread Your Application: Before submitting, carefully proofread your application materials for any spelling or grammatical errors. A polished application reflects your attention to detail, which is crucial for a scientific role.
How to prepare for a job interview at The Pirbright Institute
✨Know Your Research
Familiarise yourself with the latest research and developments in immunology and antibody discovery techniques. Be prepared to discuss how your previous work aligns with the goals of The Pirbright Institute, especially regarding vaccine development against H. contortus.
✨Demonstrate Collaboration Skills
Highlight your experience in collaborative projects and teamwork. The role requires working closely with various groups, so share examples of how you've successfully collaborated in past research settings.
✨Prepare for Technical Questions
Expect questions related to your technical skills, particularly in flow cytometry, molecular cloning, and assay design. Brush up on these topics and be ready to explain your methodologies and results clearly.
✨Show Enthusiasm for the Role
Express genuine interest in the position and the mission of The Pirbright Institute. Discuss why you are passionate about advancing vaccine research and how you can contribute to their objectives.
